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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Validating The Accuracy Of Neatwork, A Rural Gravity Fed Water Distribution System Design Program, Using Field Data In The Comarca Ngöbe-Bugle, Panama, Maria Briones
USF Tampa Graduate Theses and Dissertations
Despite the sustainable development goals to increase access to improved water there are still 884 million people in the world without access to an improved water source (WHO, 2017). One method to improve access to water in rural, mountainous areas, is through construction of gravity fed water distribution systems. These systems should be designed based upon fundamental principles of hydraulics. One method of doing so in a time efficient manner with minimal engineering knowledge is to utilize a downloadable computer program such as Neatwork, which aids in design of rural, gravity fed water distribution systems and has been used by …
A New Approach To The Development Of An Rsv Anti-Viral Targeted Nanocarrier For Dual Inhibition Of Viral Infection And Replication, Anthony N. Singer
A New Approach To The Development Of An Rsv Anti-Viral Targeted Nanocarrier For Dual Inhibition Of Viral Infection And Replication, Anthony N. Singer
USF Tampa Graduate Theses and Dissertations
Respiratory Syncytial Virus (RSV) is a potentially life-threatening respiratory pathogen that infects approximately 64 million children and immunocompromised adults globally per year. Currently, there is a need for prophylactic and therapeutic approaches effective against primary and secondary RSV infections. This project focuses on the development of a simple, smart, and scalable anti-RSV nanotherapeutic that combines novel cellular antiviral defense mechanisms targeting the inhibition of viral fusion and replication. An ICAM-1 targeted liposomal nanocarrier will be synthesized and coated with a layer of chitosan containing the anti-fusion HR2-D peptide as an extracellular defense mechanism. Additionally, chitosan complexed to dual expressing short …
Design And Testing Of A Passive Prosthetic Ankle Foot Optimized To Mimic An Able-Bodied Gait, Millicent Schlafly
Design And Testing Of A Passive Prosthetic Ankle Foot Optimized To Mimic An Able-Bodied Gait, Millicent Schlafly
USF Tampa Graduate Theses and Dissertations
Currently there are nearly 2 million people living with limb loss in the United States [1]. Many of these individuals are either transtibial (below knee) or transfemoral (above knee) amputees and require an ankle-foot prosthesis for basic mobility. While there are an abundance of options available for individuals who require an ankle-foot prosthesis, these options fail to mimic an intact ankle when it comes to key evaluation criteria such as range of motion, push-off force, and roll over shape. The roll over shape is created by plotting the center of pressure during a step in a shank-based coordinate system. To …
Elastin-Like Polypeptide Fusion Tag As A Protein-Dependent Solubility Enhancer Of Cysteine-Knot Growth Factors, Tamina L. Johnson
Elastin-Like Polypeptide Fusion Tag As A Protein-Dependent Solubility Enhancer Of Cysteine-Knot Growth Factors, Tamina L. Johnson
USF Tampa Graduate Theses and Dissertations
Elastin-like peptide (ELP) fusions promote therapeutic delivery and efficacy. Recombinant proteins, like neurotrophins, lack bioavailability, have short in vivo half-lives, and require high manufacturing costs. Fusing recombinant proteins with genetically encodable ELPs will increase bioavailability, enhance in vivo solubilization, as well as provide a cost-effective method for purification without the need for chromatography. During expression of neurotrophin-ELP (N-ELP) fusions, dense water-insoluble aggregates known as inclusion bodies (IBs) are formed. Inclusion bodies are partially and misfolded proteins that usually require denaturants like Urea for solubilization. Strong denaturants arrest ELPs stimuli-responsive property and increase unwanted aggregation, making purification difficult, yet possible. The …
Comparison Of Thermal Glove Wrist-Hand Orthoses In Their Effectiveness On Rheumatoid Arthritis, Brittany E. Mott
Comparison Of Thermal Glove Wrist-Hand Orthoses In Their Effectiveness On Rheumatoid Arthritis, Brittany E. Mott
USF Tampa Graduate Theses and Dissertations
Rheumatoid arthritis (RA) is an autoimmune disease affecting nearly 1% of the world’s population with symptoms such as inflammation, pain, and reduced strength [1]. Physicians and scientists work to develop pharmaceuticals and medical devices aimed at decreasing the symptoms associated with RA to better the lives of those affected. One of the most recent developments is the addition of thermal therapy gloves to the array of upper limb orthoses available to patients with RA. It was hypothesized that this study will show that orthoses in the form of thermal therapy gloves are beneficial to the patients by reducing symptoms such …
Developing Motion Platform Dynamics For Studying Biomechanical Responses During Exercise For Human Spaceflight Applications, Kaitlin Lostroscio
Developing Motion Platform Dynamics For Studying Biomechanical Responses During Exercise For Human Spaceflight Applications, Kaitlin Lostroscio
USF Tampa Graduate Theses and Dissertations
In future human spaceflight missions, with prolonged exposure to microgravity, resistive and aerobic exercises will be countermeasures for bone loss, muscle loss, and decreased aerobic capacity. Two of the exercises of interest are squats and rowing. The cyclic forces produced during these exercises are at relatively low frequencies which are likely to excite structural resonances of space vehicles. Vibration Isolation Systems (VIS) are being designed to be paired with future exploration exercise devices in order to prevent these cyclic exercise forces from impacting the space vehicle. The VIS may be configured such that a platform supports the human and exercise …