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Full-Text Articles in Life Sciences
Development Of Novel Allele Specific Pcr Based Assays To Investigate The Contribution Of Cortisol To Metabolic Syndrome And It's Potential Implications In Depression Treatment, Justin Robert Salm
Development Of Novel Allele Specific Pcr Based Assays To Investigate The Contribution Of Cortisol To Metabolic Syndrome And It's Potential Implications In Depression Treatment, Justin Robert Salm
Honors Theses
The shared circuitries of depression and the stress response, regulated by the Hypothalamic-Pituitary-Adrenal (HPA) axis, implies that major depression may reflect dysregulations of the HPA axis. Previous studies find that that melancholic depression is accompanied by hyperactive HPA activity, anxiety, insomnia etc. Adversely, patients with atypical depression present CRH deficiency accompanied by lethargy and fatigue. According to the corticosteroid receptor hypothesis, HPA axis dysregulation that causes these variable phenotypic depressive moods may be attributed to defective GR expression or function. Multiple GR polymorphisms that could impact its expression or function have been identified. Due to limitations, it was not feasible …
Quantification Of Hfshr Signaling To Determine Lipid Raft Residency, Gregory Geisel
Quantification Of Hfshr Signaling To Determine Lipid Raft Residency, Gregory Geisel
Honors Theses
Human follicle stimulating hormone (hFSH) is a gonadotropin responsible for regulating reproductive systems by stimulation of Sertoli cells in males and granulosa cells in females. The hFSH receptor (hFSHR) is a seven transmembrane receptor that belongs to the G protein coupled receptor family. The receptor is functionally connected to a G protein on the inside of the cell. Once FSH activates its receptor, a cascade of signaling begins, resulting in the activation of adenylyl cyclase, which increases the intracellular levels of cAMP. In addition, hFSHR stimulation also activates the p44/42 MAP kinase. The spike in cAMP activates the enzyme protein …