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Articles 1 - 9 of 9
Full-Text Articles in Life Sciences
Prep-Hplc Method Development To Isolate Potentially-Carcinogenic, Arginine-Based Heterocyclic Amines, Victoria S. Kim
Prep-Hplc Method Development To Isolate Potentially-Carcinogenic, Arginine-Based Heterocyclic Amines, Victoria S. Kim
Honors Theses
Heterocyclic amines (HCAs) are carcinogenic molecules generated from the reaction of creatin(in)e and amino acids at high cooking temperatures in meat. Previous research has shown that replacing creatine with arginine leads to new, uncharacterized HCA molecules. This research entails implementing and optimizing the preparative HPLC analysis of extracts from multiple burnings of arginine with phenylalanine. Isolated fractions from the prep-HPLC analysis were further analyzed using the Ames test to identify mutagenic compounds. Prep-HPLC provides quality control to the burning process along with isolation of larger quantities of materials for further characterization and molecular structure identification.
Molecular Mass Of L-Arginine-Based Potentially Carcinogenic Heterocyclic Amines, Irene S. Hwang
Molecular Mass Of L-Arginine-Based Potentially Carcinogenic Heterocyclic Amines, Irene S. Hwang
Honors Theses
Investigation of cancer-inducing molecules in cooked foods has led to the discovery of mutagenic heterocyclic amines (HCAs) in meat. The amino acids creatin(in)e and L-phenylalanine form the precursors for these HCAs. Recent research here at Andrews University have found similar mutagenic HCAs produced from plant-based proteins when L-arginine, rather than creatin(in)e, is substituted in high temperature reactions (simulated cooking) with L-phenylalanine. Our research focused on developing HPLC methods to isolate individual candidates that are then screened for mutagenicity via the Ames test. Mass spectroscopy methods were also developed to identfy the molecular structure of these lead mutagenic L-arginine-based HCAs.
Fluorescence Analysis Of Pamam Dendrimers, Ansel Nam
Fluorescence Analysis Of Pamam Dendrimers, Ansel Nam
Honors Theses
Despite their lack of conjugation, polyamidoamine (PAMAM) dendrimers are intrinsically fluorescent, and this fluorescent is somewhat manipulable through altering the dendrimer's solvent. This level of fluorescence is dependent on a number of the dendrimer's qualities: the pH of the solvent, the mass percent concentration of the dendrimer in solvent, and the generation size of the dendrimer. In past studies, fluorescent intensity increased as generation size increased and pH decreased. Thus, this research project will attempt to replicate those results as well as further analyze the efficiency of fluorescence of PAMAM dendrimer in comparison to fluorescein.
The Relationship Between Cold Stress Syndrome Mortality And Body Shape In Florida Manatees, Purin Chirachevin
The Relationship Between Cold Stress Syndrome Mortality And Body Shape In Florida Manatees, Purin Chirachevin
Honors Theses
West Indian manatees (Trichechus manatus latirostris) are tropical and subtropical aquatic mamals that can develop cold stress syndrome (CSS) when subjected to water temperatures below 20'C for prolonge dperiods. This study investigtes the potential impact that cold winter water temperatures in Florida may have on manatee body shape as a selective force to reduce surface-area-to-volume ratio (SA:Vol; i.e. Bergmann's and Allen's Rule). Morphometric measurements collected from state-mandated necropsies (1974-2014) were used to calculate surface area, volume, and mass. We found that manatees that died of CSS on average had significantly greater SA:Vol and less mass compared to those that died …
Soil Sand Content, But Not Solil Myrosinase Enzyme Activity, Affects Mam Efficacy In Suppressing Weed Growth, Warit Chirachevin
Soil Sand Content, But Not Solil Myrosinase Enzyme Activity, Affects Mam Efficacy In Suppressing Weed Growth, Warit Chirachevin
Honors Theses
Mustard seed meal (MSM) has been shown to control weeds and pests in crop fields. Prior work showed that a sandy loam soil was superior to a silt loam soil in supporting velvetleaf growth suppression by MSM. To explore this difference, myrosinase enzyme activity was measured in both soils. Results showed no significant difference between the soils. Sand content in Michigan silt loam soil was manipulated in order to test the role of sand content on MSM efficacy in suppressing short-term velvetleaf growth. Results showed that sand enhanced the effect of MSM in suppressing seedling growth and germination.
Synthesis Of A-Cyanostilbenes And Testing Of Their Anticancer Properties, Gabrielle Cook
Synthesis Of A-Cyanostilbenes And Testing Of Their Anticancer Properties, Gabrielle Cook
Honors Theses
This research project involves synthesizing cyanostilbenes and testing their anticancer properties in breast cancer cells. Breast cancer is a global issue, one that great improvement has been found in the last few decades, but also one that remains a large killer. The components of the cyanostilbene hybrids have all been shown to have anticancer properties on their own, and we would like to see if we can increase these properties by combining multiple into a single hybrid. Then these cyanostilbene compounds are tested on Her2+ human breast cancer cells. The goals is to assess whether or not the cyanostilbenes have …
The Role Of Octopamine In Syllable-Period Selective Phonotaxis In Female Cricket Acheta Domesticus, Darley Magno
The Role Of Octopamine In Syllable-Period Selective Phonotaxis In Female Cricket Acheta Domesticus, Darley Magno
Honors Theses
Female crickets respond phonotactically to the calls of conspecific males. Females' phonotaxis has been reported to be variable, ranging from unselective to selectve in response to calls with varying syllable periods (30-90 ms). Octopamine, an intertebrate neurotransmitter, has been reported to increase aggressive behavior in crickets, (Stevanson et al. 2005) but the effects of octopamine on behaviors such as phonotaxis have not been investigated. The goal of this study is to determine the effects of octopamine on the syllable-period selective phonotactic response of females. Results suggest a decrease in phonotactic responsiveness shown by 5-10 day-okds after prothroacic nanoinjection of octopamine.
Natural Products In Weed Control: Allyl-Isothiocyanate Effects On In Vitro Velvetleaf Seedling Growth And The Influence Of Mustard Seed Meal On Soil Bacterial Populations, Stanford Shin
Honors Theses
Past research has shown that alyl isothiocyanate (AICT) and its sister ITC compounds are effective alternatives to herbicides in reducing growth in weed seedlings. In this project the effects of mustard seed meal (MSM), a source of AITC, on plant-associated soil bacteria populations was assessed along with the effect of AITC on velvetleaf seed in vitro germination. Results show that MSM reduces bacterial levels in the soil. Velvetleaf seed germination was inbibited by micromolar levels of AITC. These results suggest that MSM has the potential to impact velvetleaf growth in the field as well as becoming a weed management tool.
Chelerythrine Chloride And Its Effects On Phonotactic Behavior In Female Crickets Acheta Domesticus, Haneul Shin
Chelerythrine Chloride And Its Effects On Phonotactic Behavior In Female Crickets Acheta Domesticus, Haneul Shin
Honors Theses
Selective phonotaxis by female crickets has been shown to be variable. Mechanisms which underlie such behavioral variability are being studied. Juvenile Hormone III is a neuromodulator that has been shown to increase selectivity in phonotactic behavior of female crickets. In an attempt to further explore its effects on the behavioral responses of femaile crickets, experiments have been performed with chelerythrine cloride that is known to have an opposite effect of Juvenile Hormone III. Chelerythrine chloride, a potent protein kinase C blocker, has been hypothesized to block the effect of Juvenile Hormone III which acts through a protein kinase C pathway, …