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Full-Text Articles in Life Sciences
Using Bioinformatics To Increase The Number Of Tumors That Can Be Treated With Existing Drug Treatments, Jonathan Dayton, Stephen Piccolo
Using Bioinformatics To Increase The Number Of Tumors That Can Be Treated With Existing Drug Treatments, Jonathan Dayton, Stephen Piccolo
Journal of Undergraduate Research
Typically, tens or even hundreds of mutations are observed in the DNA of a single tumor by the time it has been detected1-4. Knowledge of these mutations may be useful in guiding the way the tumor is treated. In some cases, if a tumor has a mutation in a certain gene, this may indicate that the tumor can be treated with a certain drug. For example, the drug Trastuzumab is a targeted therapy for breast cancer patients with mutations in the HER2 gene5. In other cases, a mutation may be able to be targeted by a drug even if the …
K-Shell Decomposition Reveals Structural Properties Of The Gene Coexpression Network Forneurodevelopment, Abdullah Ercüment Çi̇çek
K-Shell Decomposition Reveals Structural Properties Of The Gene Coexpression Network Forneurodevelopment, Abdullah Ercüment Çi̇çek
Turkish Journal of Biology
Neurodevelopment is a dynamic and complex process, which involves interactions of thousands of genes. Understanding the mechanisms of brain development is important for uncovering the genetic architectures of neurodevelopmental disorders such as autism spectrum disorder and intellectual disability. The BrainSpan dataset is an important resource for studying the transcriptional mechanisms governing neurodevelopment. It contains RNA-seq and microarray data for 13 developmental periods in 8?16 brain regions. Various important studies used this dataset, in particular to generate gene coexpression networks. The topology of the BrainSpan gene coexpression network yielded various important gene clusters, which are found to play key roles in …