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Full-Text Articles in Life Sciences
The Application Of Mesenchymal Progenitor Stem Cells For The Reduction Of Oxidative Stress In Animals, Edyta Wojtas, Andrzej Zachwieja, Anna Zwyrzykowska, Robert Kupczynski, Krzysztof Marycz
The Application Of Mesenchymal Progenitor Stem Cells For The Reduction Of Oxidative Stress In Animals, Edyta Wojtas, Andrzej Zachwieja, Anna Zwyrzykowska, Robert Kupczynski, Krzysztof Marycz
Turkish Journal of Biology
Oxidative stress is the primary cause of lowering of the body's immune status. It arises as a result of intense metabolic processes in humans and animals that involve a decrease in antioxidant enzymes activity at the expense of increased production of free radicals and reactive oxygen species (ROS). Consequently, this leads to oxidation of lipids, proteins, DNA, and RNA, causing cell proliferation reduction, faster cell aging, and subsequent degradation. Currently, there is a search for methods to maintain an oxidation-antioxidant balance. The results of many authors' research point to the effectiveness of the use of mesenchymal stem cells (MSCs) in …
Pt(Iv), Pd(Ii), And Rh(Iii) Complexes Induced Oxidative Stress And Cytotoxicity In The Hct-116 Colon Cancer Cell Line, Petar Canovic, Jovana Bogojeski, Jelena Kosaric, Snezana Markovic, Marko Zivanovic
Pt(Iv), Pd(Ii), And Rh(Iii) Complexes Induced Oxidative Stress And Cytotoxicity In The Hct-116 Colon Cancer Cell Line, Petar Canovic, Jovana Bogojeski, Jelena Kosaric, Snezana Markovic, Marko Zivanovic
Turkish Journal of Biology
The use of transition metal complexes as appropriate analogues to cisplatin and similar anticancer drugs nowadays is of utmost importance. The inertness of Pt(IV), Pd(II), and Rh(III) complexes and the choosing of convenient ligands could offer a possible advantage in comparison to Pt(II) complexes. These advantages could be attributed to the better anticancer activity and fewer possible side effects. In this paper, we have chosen three complexes of different transition metal ions, [(TLtBu)PdIICl]ClO4, [RhIII(LH2tBu)Cl3], and [PtIV(LH2tBu)Cl3]Cl (where TLtBu is 2,6-bis[(1,3-di-tert-butylimidazolin-2-imino)methyl]pyridine and LH2tBu is 2,6-bis(5-tert-butyl-1H-pyrazol-3-yl)pyridine), for biological tests. All three complexes exerted strong prooxidative and cytotoxic effects on the human colorectal …
Differential Oxidative Response To Fluoropyrimidines In Colorectal Cancer Cell Lines, Ufuk Özer, Karen Wood Barbour
Differential Oxidative Response To Fluoropyrimidines In Colorectal Cancer Cell Lines, Ufuk Özer, Karen Wood Barbour
Turkish Journal of Biology
Colorectal cancer (CRC) is the second most common human malignancy in women and the third in men, accounting for approximately 8% of cancer-related deaths and 1.3 million newly diagnosed cases annually worldwide. CRC cell lines differ in morphological features, growth rate, and their genetic alterations, implicating the extent of variability among the lines. The goal of the current study was to investigate the phenotypes of CRC lines related to NADPH oxidase (NOX) activity and expression of NOX2 subunits in response to fluoropyrimidines. NOX activity in response to 5'-fluoro-2'-deoxyuridine (FdUrd) and VAS2780 was measured in CRC cell lines. Cells were treated …
Neuropeptide Y Reduces Migration Capacity Of Human Choriocarcinomacell Line By Altering Oxidative/Antioxidative Status, Milos Matic, Milica Paunovic, Branka Ognjanovic, Andras Stajn, Zorica Saicic
Neuropeptide Y Reduces Migration Capacity Of Human Choriocarcinomacell Line By Altering Oxidative/Antioxidative Status, Milos Matic, Milica Paunovic, Branka Ognjanovic, Andras Stajn, Zorica Saicic
Turkish Journal of Biology
Reduced migration capacity of trophoblast cells leads to poor placentation and correlates with severe pregnancy disorders such as intrauterine growth restriction and preeclampsia. Neuropeptide Y (NPY) is sympathetic cotransmitter involved in various physiological processes and its levels are significantly increased in preeclamptic pregnancy compared to healthy pregnancy. In this study the prooxidative role of NPY and its effects on migration capacity of human trophoblast cell line JEG-3 were investigated together with the effects of nitric oxide (NO) depletion, a molecule that was shown to play an important role in promoting cell migration. The cells were treated for 24 h (short-term …