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Full-Text Articles in Life Sciences
Editorial: Murine Models Of Leukemia And Lymphoma, Christine E. Cutucache, Pierluigi Porcu
Editorial: Murine Models Of Leukemia And Lymphoma, Christine E. Cutucache, Pierluigi Porcu
Biology Faculty Publications
Murine models serve as an effective way to mimic the in vivo tumor microenvironmental interactions that take place in patients with leukemias and lymphomas. Specifically, leukemias and lymphomas rely heavily on the surrounding stroma and tissue microenvironmental cytokine and chemokine signals to ensure survival and expansion of tumor cells. Finally, leukemic cells migrate thanks to signals from varying regions of the host, furthering the progression and severity of disease. It is therefore impossible to fully understand such a dynamic relationship between tumor cells and their surrounding microenvironment, and the events to transformation in leukemias and lymphomas without an in vivo, …
Using Murine Models To Understand Tumor-Lymphoid Interactions: Spotlight On Cll And Aitl, Tyler Herek, Christine E. Cutucache
Using Murine Models To Understand Tumor-Lymphoid Interactions: Spotlight On Cll And Aitl, Tyler Herek, Christine E. Cutucache
Biology Faculty Publications
The role of the tumor microenvironment in leukemias and lymphomas is well-established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two Non-Hodgkin’s lymphoma subtypes: chronic lymphocytic leukemia and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore …