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Using A Mouse Model To Investigate Male Bias In Autism Spectrum Disorder Incidence., Elizabeth Ann Gordon
Using A Mouse Model To Investigate Male Bias In Autism Spectrum Disorder Incidence., Elizabeth Ann Gordon
Electronic Theses and Dissertations
The review (Chapter 1) overviews our current understanding of the sex bias in autism spectrum disorders (ASD), whereby males are 4 times more likely to develop the condition. The longstanding uncertainty surrounding the etiology of autism can be informed by inclusion of both sexes in future research to better understand the mechanism responsible for this sex bias. Both clinical studies and animal models are useful tools to elucidate the underlying cause(s) of sexual dimorphic morphological, physiological, and behavioral differences in the ASD phenotype. Sex differences in social behaviors are common across species, underscoring the importance of assessing baseline sex differences …