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Murine Models Of Splenic Marginal Zone Lymphoma: A Role For Cav1?, Chelsey L. Patten, Christine E. Cutucache
Murine Models Of Splenic Marginal Zone Lymphoma: A Role For Cav1?, Chelsey L. Patten, Christine E. Cutucache
Biology Faculty Publications
Dozens of murine models of indolent and aggressive B-cell lymphomas have been generated to-date. These include those manifesting chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL) as well as xenografts of mantle cell lymphoma (MCL). These models have led to an improved understanding of disease etiology, B-cell biology, immunomodulation, and the importance of the tumor microenvironment. Despite these efforts in CLL, DLBCL, and MCL, considerably little progress toward a model of splenic marginal zone lymphoma (SMZL) has been accomplished. Herein, we describe the similarities and differences between CLL, MCL, and SMZL, and highlight effective murine models that mimic disease …
Burrowing Through The Heterogeneity: Review Of Mouse Models Of Ptcl-Nos, Christine E. Cutucache, Tyler Herek
Burrowing Through The Heterogeneity: Review Of Mouse Models Of Ptcl-Nos, Christine E. Cutucache, Tyler Herek
Biology Faculty Publications
Currently, there are 19 different peripheral T-cell lymphoma (PTCL) entities recognized by the World Health Organization; however, ~70% of PTCL diagnoses fall within one of three subtypes [i.e., peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), anaplastic large-cell lymphoma, and angioimmunoblastic T-cell lymphoma]. PTCL-NOS is a grouping of extra-thymic neoplasms that represent a challenging and heterogeneous subset of non-Hodgkin’s lymphomas. Research into peripheral T-cell lymphomas has been cumbersome as the lack of defining cytogenetic, histological, and molecular features has stymied diagnosis and treatment of these diseases. Similarly, the lacks of genetically manipulated murine models that faithfully recapitulate disease characteristics were absent …