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Murine Models Of Splenic Marginal Zone Lymphoma: A Role For Cav1?, Chelsey L. Patten, Christine E. Cutucache
Murine Models Of Splenic Marginal Zone Lymphoma: A Role For Cav1?, Chelsey L. Patten, Christine E. Cutucache
Biology Faculty Publications
Dozens of murine models of indolent and aggressive B-cell lymphomas have been generated to-date. These include those manifesting chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL) as well as xenografts of mantle cell lymphoma (MCL). These models have led to an improved understanding of disease etiology, B-cell biology, immunomodulation, and the importance of the tumor microenvironment. Despite these efforts in CLL, DLBCL, and MCL, considerably little progress toward a model of splenic marginal zone lymphoma (SMZL) has been accomplished. Herein, we describe the similarities and differences between CLL, MCL, and SMZL, and highlight effective murine models that mimic disease …