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Simulation Comparison Of Statistical Methods Used In Assessing Vaccine Efficacy In Veterinary Biologics, Kenny Wakeland, Brian Fergen

Conference on Applied Statistics in Agriculture

In veterinary biologics, clinical studies conducted to support the licensure of a vaccine generally include a demonstration of efficacy in the species of interest. Typically, these studies are designed to assess a vaccine’s ability to prevent or mitigate clinical disease. Study designs utilize two or more treatment groups, and often incorporate blocking structure restrictions to accommodate animal housing or litter-related effects. When assessing a vaccine’s ability to prevent clinical disease, the prevented fraction (PF), a function of the group proportions of affected animals, is often utilized. Typically the sample size per treatment group is limited, and each block is represented …