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Articles 1 - 5 of 5
Full-Text Articles in Life Sciences
Amygdala Pacap As A Mediator Of The Emotional Components Of Pain, Galen Missig
Amygdala Pacap As A Mediator Of The Emotional Components Of Pain, Galen Missig
Graduate College Dissertations and Theses
Chronic pain alters sensory responses and carries a strong emotional component. Persistent pain can heighten pain experiences, resulting in hyperalgesia and allodynia. Further, patients suffering from chronic pain are more prone to experience a range of affective disorders including depression, sleep dysregulation, panic disorders, anxiety abnormalities and stress-related disorders including post-traumatic stress disorder (PTSD). Hence while pain serves a protective function to prevent additional physiological harm by driving behavioral and cognitive responses, chronic or persistent pain can lead to maladaptive nociceptive responses and exacerbate psychopathologies. Among brain regions, the amygdala is centrally situated to integrate the many descending and ascending …
The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
Graduate College Dissertations and Theses
Disorders such as schizophrenia (SCZ) and austism spectrum disorder (ASD) have long been associated with prenatal stress. In these three experiments, we attempted to correlate stress during gestation with behaviors considered to have good facial validity with SCZ and ASD in both juvenile and adult animals. To differentiate the effects of prenatal stress (PS) from the effects of early life stress due to a dam's behavior (MS), half of offspring animals were cross fostered to dams treated in the alternative condition as the offspring during pregnancy in experiments 2 and 3. In experiment 1, but not in 2 or 3, …
The Role Of Estrogen In Emotional And Cognitive Processes Integral To Major Depressive Disorder, Kimberly Albert
The Role Of Estrogen In Emotional And Cognitive Processes Integral To Major Depressive Disorder, Kimberly Albert
Graduate College Dissertations and Theses
Women have greater incidence and prevalence of Major Depressive Disorder (MDD) than men during the reproductive life phase when ovarian hormones fluctuate, suggesting that ovarian hormones have a significant role in MDD etiology in women. As the core symptoms of MDD are indicative of alterations in stress responding, emotional processing, and mood regulation, examining the effects of the estrogen on these processes in women may provide a better understanding of the role of estrogen in the sex difference in MDD rates. The general aim of this dissertation was to examine neural, emotional, and attentional processes related to stress response alterations …
Lexical Mechanics: Partitions, Mixtures, And Context, Jake Ryland Williams
Lexical Mechanics: Partitions, Mixtures, And Context, Jake Ryland Williams
Graduate College Dissertations and Theses
Highly structured for efficient communication, natural languages are complex systems. Unlike in their computational cousins, functions and meanings in natural languages are relative, frequently prescribed to symbols through unexpected social processes. Despite grammar and definition, the presence of metaphor can leave unwitting language users "in the dark," so to speak. This is not problematic, but rather an important operational feature of languages, since the lifting of meaning onto higher-order structures allows individuals to compress descriptions of regularly-conveyed information. This compressed terminology, often only appropriate when taken locally (in context), is beneficial in an enormous world of novel experience. However, what …
Nicotinic Signaling: Alpha3 Beta4 Heteromers, Alpha5 Subunits, And The Prototoxin Lypd6b, Vanessa Ochoa
Nicotinic Signaling: Alpha3 Beta4 Heteromers, Alpha5 Subunits, And The Prototoxin Lypd6b, Vanessa Ochoa
Graduate College Dissertations and Theses
Prototoxin proteins have been identified as members of the Ly6/uPAR super family whose three-finger motif resembles that of α-bungarotoxin. Though they are known to modify the function of nAChRs, their specificity is still unclear. Our lab identified three prototoxin proteins in the chicken ciliary ganglion: Ch3ly, Ch5ly, and Ch6ly. Ch6ly was later identified as prostate stem cell antigen (PSCA), and specifically decreased the amount of calcium influx through the homomeric α7 nAChR subtype. I then identifiedCh3ly and Ch5ly as LY6E and LYPD6B, respectively. I focused my attention onLYPD6B because of its expression in the brain. This dissertation tests whether LYPD6Bis …