Life Sciences Commons^™

Special Muscles, Annamaria C. Scaccia

Capstones

Special Muscles is a documentary that explores living with Duchenne muscular dystrophy, a fatal degenerative disease that weakens the muscles at an aggressive rate. The film will give an uncensored look at how one family copes with inevitability of the disease and their journey chasing a promising experimental cure.

Special Muscles follows 7-year-old Pietro Scarso and his family as they face the challenges, complications and promise of treating Pietro’s progressive muscle disorder. The film travels from New York to Los Angeles to Philadelphia to document the Scarso family’s race against time as Pietro undergoes a 96-week clinical trial for Eteplirsen, …

The Neurophysiology Of Intersensory Selective Attention And Task Switching, Jeremy W. Murphy

Dissertations, Theses, and Capstone Projects

Our ability to selectively attend to certain aspects of the world and ignore others is fundamental to our day-to-day lives. The need for selective attention stems from capacity limitations inherent in our perceptual and cognitive processing architecture. Because not every elemental piece of our environment can be fully processed in parallel, the nervous system must prioritize processing. This prioritization is generally referred to as selective attention. Meanwhile, we are faced with a world that is constantly in flux, such that we have to frequently shift our attention from one piece of the environment to another and from one task to …

Tonic And Phasic Inhibitory Mechanisms Mediating Sensorimotor Decision-Making In The Goldfish Auditory Startle Circuit, Paul C.P. Curtin

Dissertations, Theses, and Capstone Projects

This work describes related studies of cellular and synaptic signaling mechanisms involved in the balance of excitation and inhibition in the goldfish auditory startle circuit. The general purpose of these experiments was to identify novel mechanisms that contribute to action selection at different stages of the motor control hierarchy. The methods applied to achieve this goal tested the effects of selective antagonists for target receptor systems on sound-evoked excitation and inhibition of startle.

Chapter 2 describes a study of a poorly-understood serotonergic mechanism, the 5-HT_5A receptor, that was not previously functionally characterized in native tissues or associated with neural …

Neural Mechanisms Underlying The Perception Of Three-Dimensional Shape From Texture: Adaptation And Aftereffects, Carole Filangieri

Dissertations, Theses, and Capstone Projects

Input into the visual system is two-dimensional (2D) and yet we effortlessly perceive the world around us as three-dimensional (3D). How we are able to accurately extract 3D shape information from the 2D representations that fall on the retina remains largely unknown. Although much research has been conducted that investigates higher levels of form processing (i.e. face recognition), less is known about the mechanisms that underlie the perception of simple 3D shape. Previous studies in our lab have shown that our ability to perceive 3D shape from texture cues relies on the visibility of orientation flows -- patterns that run …

Physiological And Subjective Aspects Of Positive Mood In Relation To Executive Functioning: The Potential Moderating Role Of Personality, Luz Helena Ospina

Dissertations, Theses, and Capstone Projects

Positive affect has been demonstrated to improve aspects of cognition. However, recent studies reveal that positive affect may hinder the same cognitive processes, such as executive functioning, memory and creativity. These discrepant findings may be due to differing levels of physiological arousal, a component of the circumplex model of affect, which has been largely ignored in affective research. For example, one recent study suggests that positive valence coupled with varying levels of physiological arousal (i.e., low, moderate, and high) may differentially affect performance on tasks of verbal fluency and memory. Furthermore, one other explanation for these inconsistent findings may relate …