Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Genome-Wide Detection And Analysis Of Multifunctional Genes, Yuri Pritykin, Dario Ghersi, Mona Singh
Genome-Wide Detection And Analysis Of Multifunctional Genes, Yuri Pritykin, Dario Ghersi, Mona Singh
Interdisciplinary Informatics Faculty Publications
Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular functioning, thereby leading to a better understanding of the functional landscape of the cell. However, to date, genome-wide analysis of multifunctional genes (and the proteins they encode) has been limited. Here we introduce a computational approach that uses known functional annotations to extract genes playing a role in at least two distinct biological processes. We leverage functional genomics data sets for three organisms—H. sapiens, …
Is Trust Always Better Than Distrust? The Potential Value Of Distrust In Newer Virtual Teams Engaged In Short-Term Decision-Making, Paul Benjamin Lowry, Ryan M. Schuetzler, Justin Scott Giboney, Thomas A. Gregory
Is Trust Always Better Than Distrust? The Potential Value Of Distrust In Newer Virtual Teams Engaged In Short-Term Decision-Making, Paul Benjamin Lowry, Ryan M. Schuetzler, Justin Scott Giboney, Thomas A. Gregory
Information Systems and Quantitative Analysis Faculty Publications
The debate on the benefits of trust or distrust in groups has generated a substantial amount of research that points to the positive aspects of trust in groups, and generally characterizes distrust as a negative group phenomenon. Therefore, many researchers and practitioners assume that trust is inherently good and distrust is inherently bad. However, recent counterintuitive evidence obtained from face-to-face (FtF) groups indicates that the opposite might be true; trust can prove detrimental, and distrust instrumental, to decision-making in groups. By extending this argument to virtual teams (VTs), we examined the value of distrust for VTs completing routine and non-routine …
Coexpression Network Analysis Of Mirna-142 Overexpression In Neuronal Cells, Ishwor Thapa, Howard S. Fox, Dhundy Raj Bastola
Coexpression Network Analysis Of Mirna-142 Overexpression In Neuronal Cells, Ishwor Thapa, Howard S. Fox, Dhundy Raj Bastola
Interdisciplinary Informatics Faculty Publications
MicroRNAs are small noncoding RNA molecules, which are differentially expressed in diverse biological processes and are also involved in the regulation of multiple genes. A number of sites in the 3′ untranslated regions (UTRs) of different mRNAs allow complimentary binding for a microRNA, leading to their posttranscriptional regulation. The miRNA-142 is one of the microRNAs overexpressed in neurons that is found to regulate SIRT1 and MAOA genes. Differential analysis of gene expression data, which is focused on identifying up- or downregulated genes, ignores many relationships between genes affected by miRNA-142 overexpression in a cell. Thus, we applied a correlation network …
On The Comparison Of State- And Transition-Based Analysis Of Biological Relevance In Gene Co-Expression Networks, Kathryn Dempsey Cooper, Prasuna Vemuri, Hesham Ali
On The Comparison Of State- And Transition-Based Analysis Of Biological Relevance In Gene Co-Expression Networks, Kathryn Dempsey Cooper, Prasuna Vemuri, Hesham Ali
Interdisciplinary Informatics Faculty Proceedings & Presentations
Traditional correlation network analysis typically involves creating a network using gene expression data and then identifying biologically relevant clusters from that network by enrichment with Gene Ontology or pathway information. When one wants to examine these networks in a dynamic way - such as between controls versus treatment or over time - a "snapshot" approach is taken by comparing network structures at each time point. The biological relevance of these structures are then reported and compared. In this research, we examine the same "snapshot" networks but focus on the enrichment of changes in structure to determine if these results give …