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Species Interactions Differ In Their Genetic Robustness, Lon M. Chubiz, Brian R. Granger, Daniel Segrè, William R. Harcombe
Species Interactions Differ In Their Genetic Robustness, Lon M. Chubiz, Brian R. Granger, Daniel Segrè, William R. Harcombe
Lon Chubiz
Conflict and cooperation between bacterial species drive the composition and function of microbial communities. Stability of these emergent properties will be influenced by the degree to which species’ interactions are robust to genetic perturbations. We use genome-scale metabolic modeling to computationally analyze the impact of genetic changes when Escherichia coli and Salmonella enterica compete, or cooperate. We systematically knocked out in silico each reaction in the metabolic network of E. coli to construct all 2583 mutant stoichiometric models. Then, using a recently developed multi-scale computational framework, we simulated the growth of each mutant E. coli in the presence of S. …