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Articles 1 - 9 of 9
Full-Text Articles in Life Sciences
Meta-Analysis Of Dna Methylation And Expression In Liver Cancer Patients, Daniele Todorov, Barbara Stefanska, Katarzyna Lubecka-Pietruszewska
Meta-Analysis Of Dna Methylation And Expression In Liver Cancer Patients, Daniele Todorov, Barbara Stefanska, Katarzyna Lubecka-Pietruszewska
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hepatocellular carcinoma (HCC), the most common liver cancer, is the second leading cause of cancer-related death worldwide. HCC is often diagnosed at late stages, for which there are no effective chemotherapies. Biomarkers unique to HCC patients could be used to detect HCC early and improve treatment. In the present project, we have performed a meta-analysis to compare the gene-specific DNA methylation and gene expression patterns of HCC patients as reported by four independent studies. Our goal was to discover the strongest changes that distinguish HCC from normal tissue. The relationship between methylation and expression in HCC was examined and genes …
Using The Intact Method To Study Pickle In Individual Cell Types, Jacqueline L. Phipps, Daniela N. Martir, Ben Carter, Joe Ogas
Using The Intact Method To Study Pickle In Individual Cell Types, Jacqueline L. Phipps, Daniela N. Martir, Ben Carter, Joe Ogas
The Summer Undergraduate Research Fellowship (SURF) Symposium
Cell differentiation is an essential part of development in multicellular organisms. Cells with identical genomic DNA are able to differentiate into a variety of tissues due to selective expression and repression of genes. This tissue-specific gene expression is enabled in part by proteins called chromatin remodelers, which can move, remove, or restructure histone proteins to restrict or allow physical access to genomic DNA. PICKLE (PKL) is a member of the CHD family of ATP-dependent chromatin remodelers that promotes cellular identity in the plant model organism Arabidopsis thaliana. PKL promotes cell identity by silencing embryonic genes during seed germination by promoting …
Captive Breeding Protocols And Their Impact On Genetic Diversity In White-Footed Mice (Peromyscus Leucopus): Implications For Threatened And Endangered Species, Maureen C. Lamb, Janna R. Willoughby, J. Andrew Dewoody
Captive Breeding Protocols And Their Impact On Genetic Diversity In White-Footed Mice (Peromyscus Leucopus): Implications For Threatened And Endangered Species, Maureen C. Lamb, Janna R. Willoughby, J. Andrew Dewoody
The Summer Undergraduate Research Fellowship (SURF) Symposium
Captive breeding protocols used in zoos often are aimed at increasing population sizes and retaining genetic diversity of endangered species. However, captive breeding causes genetic adaptation to captivity that can lead to an overall decrease in genetic diversity and reduce chances of a successful reintroduction to the wild. In this study, we assess how 3 different breeding protocols—random mating, preferential breeding of individuals with the lowest mean kinship scores, and selection for docility—affect the variability of mitochondrial DNA in white-footed mice (Peromyscus leucopus). We used mice that were captured from the wild but were mated for up to …
A Screen To Identify Saga-Activated Genes That Are Required For Proper Photoreceptor Axon Targeting In Drosophila Melanogaster, Kaelan J. Brennan, Vikki M. Weake, Jingqun Q. Ma
A Screen To Identify Saga-Activated Genes That Are Required For Proper Photoreceptor Axon Targeting In Drosophila Melanogaster, Kaelan J. Brennan, Vikki M. Weake, Jingqun Q. Ma
The Summer Undergraduate Research Fellowship (SURF) Symposium
The inherited human genetic disease spinocerebellar ataxia type 7 (SCA7) is characterized by progressive neurodegeneration and visual impairment that ultimately leads to blindness. SCA7 results from a mutation in the human ATXN7 gene that causes an expansion of polyglutamine tracts in this gene’s corresponding protein. Human ATXN7 protein serves as a component of the deubiquitylase (DUB) module of the large, multi-subunit complex Spt-Ada-Gcn acetyltransferase, or SAGA. SAGA is a transcriptional coactivator and histone modifier that functions to deubiquitylate histone H2B and allow for transcription of SAGA-mediated genes to occur. In Drosophila, mutations in SAGA DUB’s Nonstop and sgf11 components …
Detecting Genomic Regions Responsible For Resistance In Arabidopsis, Valeria Cancino, Anjali Iyer-Pascuzzi, Rucha Karve
Detecting Genomic Regions Responsible For Resistance In Arabidopsis, Valeria Cancino, Anjali Iyer-Pascuzzi, Rucha Karve
The Summer Undergraduate Research Fellowship (SURF) Symposium
Ralstonia solanacearum is a soil-borne plant root colonizing pathogen and the casual agent of bacterial wilt (BW) disease. BW leads to severe yield loss in a wide variety of agricultural commodity crops, such as tomato, banana, and pepper. In this study, we look at the plant-pathogen interaction between Ralstonia solanacearum and various ecotypes of Arabidopsis thaliana with the goal of finding resistant ecotypes. To identify resistant ecotypes, seeds are first sterilized and left to soak in the dark. Then the seeds are plated on agar media, transferred to a growth chamber, and allowed to grow for 5 days. On day …
Genetic, Agronomic And Compositional Characterization Of Brown Midrib Sweet Sorghum Lignocellulosic Biomass For Ethanol Production, Luis A. Rivera Burgos
Genetic, Agronomic And Compositional Characterization Of Brown Midrib Sweet Sorghum Lignocellulosic Biomass For Ethanol Production, Luis A. Rivera Burgos
Open Access Dissertations
Sorghum is a promising bioenergy crop due to its unique phenotypic and genotypic attributes. Quality (low lignin and high stem sugar concentration) and quantity (biomass yield, plant height, plant maturity, etc.) biomass traits are key contributors to ethanol yield and production. In this study, a 236 sorghum recombinant inbred line (RIL) population was subjected to genetic, agronomic and compositional characterization for ethanol yield and production. We found that the sweet mutation enhances biomass quantity traits in the RILs which translates to higher ethanol production and biomass quality which improves ethanol yield. The variance components showed from moderate to high heritability …
Genetic Analysis Of Tocochromanol Variation In Maize Using High-Density Linkage Mapping, Megan E. Fenton
Genetic Analysis Of Tocochromanol Variation In Maize Using High-Density Linkage Mapping, Megan E. Fenton
Open Access Theses
Vitamin E is an essential nutrient in the human diet and refers to eight distinct compounds that are collectively known as tocochromanols. Tocochromanols are grouped into two classes: tocotrienols and tocopherols. Tocochromanols are the major lipid-soluble antioxidants in maize (Zea mays L.) grain. Enhancing the tocochromanol content of maize derived foods through plant breeding has important nutritional and health implications. Chapter one is a literature review that provides a foundational understanding of the biosynthesis, function and genetic control of tocochromanols in plants, with specific attention to maize (Zea mays L.). Upon this foundation two research objectives were developed that work …
Utilization Of Tall Wheatgrass Translocation Lines To Improve Fusarium Head Blight Resistance In Wheat, Xiangye Xiao
Utilization Of Tall Wheatgrass Translocation Lines To Improve Fusarium Head Blight Resistance In Wheat, Xiangye Xiao
Open Access Dissertations
Fusarium head blight (FHB) and leaf rust (LR) are two major fungal pathogens threatening the wheat crop, consequently identifying resistance genes from various sources is always of importance to wheat breeders. Type II FHB resistance in wheat has been improved by introgressing QTL from landraces and wild species. The present study was undertaken to (1) combine two different type II FHB resistance QTL in the backgrounds of six adapted wheat lines (2) improve the map resolution of Qfhs.pur-7EL.^ In the first objective, the FHB resistance gene Fhb1 originated in a Chinese wheat cultivar and is located on wheat chromosome …
Using Large Snp Datasets To Understand The Genetic Mechanisms Of Complex Traits In Arabidopsis Thaliana, Elisabeth S. Harrison
Using Large Snp Datasets To Understand The Genetic Mechanisms Of Complex Traits In Arabidopsis Thaliana, Elisabeth S. Harrison
Open Access Theses
Arabidopsis thaliana, as a model species, has been widely genotyped and sequenced. Many studies have been done to understand the kinship and population structure of the species. This data and information is beneficial for understanding the genetic mechanisms of complex traits. In this thesis, we first used genotyped data for 5,967 accessions to study the occurrence of tetraploidy in the species. We found that tetraploidy is a transient character state, and the species is a diploid species. Secondly, we used 211K and 1.6M SNPs for 440 accessions to run genome-wide analyses (GWA) for four traits: glufosinate tolerance, hybrid incompatibilities, seed …