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Full-Text Articles in Life Sciences
The Crimson Conundrum: Heme Toxicity And Tolerance In Gas, Ankita J. Sachla, Yoann Le Breton, Fahmina Akhter, Kevin S. Mciver, Zehava Eichenbaum, Ankita J. Sachla
The Crimson Conundrum: Heme Toxicity And Tolerance In Gas, Ankita J. Sachla, Yoann Le Breton, Fahmina Akhter, Kevin S. Mciver, Zehava Eichenbaum, Ankita J. Sachla
Biology Faculty Publications
The massive erythrocyte lysis caused by the Group A Streptococcus (GAS) suggests that the β-hemolytic pathogen is likely to encounter free heme during the course of infection. In this study, we investigated GAS mechanisms for heme sensing and tolerance. We compared the minimal inhibitory concentration of heme among several isolates and established that excess heme is bacteriostatic and exposure to sub-lethal concentrations of heme resulted in noticeable damage to membrane lipids and proteins. Pre-exposure of the bacteria to 0.1 μM heme shortened the extended lag period that is otherwise observed when naive cells are inoculated into heme-containing medium, implying that …