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Full-Text Articles in Life Sciences
Cyclodextrin Complexes Of Reduced Bromonoscapine In Guar Gum Microspheres Enhance Colonic Drug Delivery, Jitender Madan, Sushma R. Gundala, Bharat Baruah, Mulpuri Nagaraju, Clayton Yates, Timothy Turner, Vijay Rangari, Donald Hamelberg, Michelle D. Reid, Ritu Aneja
Cyclodextrin Complexes Of Reduced Bromonoscapine In Guar Gum Microspheres Enhance Colonic Drug Delivery, Jitender Madan, Sushma R. Gundala, Bharat Baruah, Mulpuri Nagaraju, Clayton Yates, Timothy Turner, Vijay Rangari, Donald Hamelberg, Michelle D. Reid, Ritu Aneja
Biology Faculty Publications
Here, we report improved solubility and enhanced colonic delivery of reduced bromonoscapine (Red-Br-Nos), a cyclic ether brominated analogue of noscapine, upon encapsulation of its cyclodextrin (CD) complexes in bioresponsive guar gum microspheres (GGM). Phase−solubility analysis suggested that Red-Br-Nos complexed with β-CD and methyl-β-CD in a 1:1 stoichiometry, with a stability constant (Kc) of 2.29 × 103 M−1 and 4.27 × 103 M−1. Fourier transforms infrared spectroscopy indicated entrance of an O−CH2 or OCH3−C6H4−OCH3 moiety of Red-Br-Nos in the β-CD or methyl-β- CD cavity. Furthermore, the cage complex of Red-Br-Nos with β-CD and methyl-β-CD was validated by several spectral techniques. Rotating …