Life Sciences Commons^™

The Neurodevelopment Of Basic Sensory Processing And Integration In Autism Spectrum Disorder, Alice Brown Brandwein

Dissertations, Theses, and Capstone Projects

This thesis presents three studies that together explore the neurophysiological basis for the sensory processing and integration abnormalities that have been observed in autism spectrum disorder (ASD) since the disorder was first described over half a century ago. In designing these studies we seek to fill a hole that currently exists in the research community‟s knowledge of the neurodevelopment of basic multisensory integration -- both in children with autism and as well as in those with typical development. The first study applied event related potentials (ERPs) and behavioral measures of multisensory integration to a large group of healthy participants ranging …

On The Role Of Neuronal Oscillations In Auditory Cortical Processing, Monica Noelle O'Connell

Dissertations, Theses, and Capstone Projects

Although it has been over 100 years since William James stated that "everyone knows what attention is", its underlying neural mechanisms are still being debated today. The goal of this research was to describe the physiological mechanisms of auditory attention using direct electrophysiological recordings in macaque primary auditory cortex (A1). A major focus of my research was on the role ongoing neuronal oscillations play in attentional modulation of auditory responses in A1.

For all studies, laminar profiles of synaptic activity, (indexed by current source density analysis) and concomitant firing patterns in local neurons (multiunit activity) were acquired simultaneously via linear …