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Pharmacological Analysis Of Dopamine Modulation In The Drosophila Melanogaster Larval Heart, Josh S. Titlow, Jenna M. Rufer, Kayla E. King, Robin L. Cooper
Pharmacological Analysis Of Dopamine Modulation In The Drosophila Melanogaster Larval Heart, Josh S. Titlow, Jenna M. Rufer, Kayla E. King, Robin L. Cooper
Biology Faculty Publications
Dopamine (DA) and other neurotransmitters affect nonneuronal tissues in insects by circulating in the hemolymph. In several organisms, DA has been shown to modulate distinct aspects of cardiac function but the signal transduction pathways that mediate dopaminergic effects on the heart are not well characterized. Here, we used a semiintact Drosophila melanogaster larva preparation and drugs targeting DA receptors and canonical second messenger pathways to identify signaling cascades that mediate the effect of DA on a myogenic heart. DA has a positive chronotropic effect that is mimicked by SKF38393 (type‐1 DA receptor agonist) and quinpirole (type‐2 DA receptor agonist). SCH23390 …