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The Survivin And Ciap1 Anti-Apoptotic Proteins Are Differentially Downregulated In Response To Endoplasmic Reticulum Stress, Vicki Mercado, Jay L. Brewster
The Survivin And Ciap1 Anti-Apoptotic Proteins Are Differentially Downregulated In Response To Endoplasmic Reticulum Stress, Vicki Mercado, Jay L. Brewster
Featured Research
The endoplasmic reticulum (ER) is an organelle tasked with synthesis and transport of 50% of new cellular proteins. Dysfunction within this organelle creates signals for repair, adaptation, and in severe cases, cellular apoptosis. Multiple human diseases have been associated with ER dysfunction, and the activation of apoptosis in important populations of cells. Inhibitor of Apoptosis (IAP) proteins are cytosolic proteins that play an anti-apoptotic role in the cytosol. The relationship between endoplasmic reticulum (ER) stress and the expression/stability of IAPs is not well characterized. The objective of this study was to characterize the affect of ER stress on the expression/stability …