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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Hypoxia And Hypoxia Inducible Factors: Diverse Roles In Liver Diseases, Bharath Nath, Gyongyi Szabo
Hypoxia And Hypoxia Inducible Factors: Diverse Roles In Liver Diseases, Bharath Nath, Gyongyi Szabo
Gyongyi Szabo
Hypoxia has been shown to have a role in the pathogenesis of several forms of liver disease. The hypoxia inducible factors (HIFs) are a family of evolutionarily conserved transcriptional regulators that affect a homeostatic response to low oxygen tension and have been identified as key mediators of angiogenesis, inflammation, and metabolism. In this review we summarize the evidence for a role of HIFs across a range of hepatic pathophysiology. We describe regulation of the HIFs and review investigations that demonstrate a role for HIFs in the development of liver fibrosis, activation of innate immune pathways, hepatocellular carcinoma, as well as …
Plasma Microrna Profiles Distinguish Lethal Injury In Acetaminophen Toxicity: A Research Study, Jeanine Ward, Shashi Bala, Jan Petrasek, Gyongyi Szabo
Plasma Microrna Profiles Distinguish Lethal Injury In Acetaminophen Toxicity: A Research Study, Jeanine Ward, Shashi Bala, Jan Petrasek, Gyongyi Szabo
Gyongyi Szabo
AIM: To investigate plasma microRNA (miRNA) profiles indicative of hepatotoxicity in the setting of lethal acetaminophen (APAP) toxicity in mice. METHODS: Using plasma from APAP poisoned mice, either lethally (500 mg/kg) or sublethally (150 mg/kg) dosed, we screened commercially available murine microRNA libraries (SABiosciences, Qiagen Sciences, MD) to evaluate for unique miRNA profiles between these two dosing parameters. RESULTS: We distinguished numerous, unique plasma miRNAs both up- and downregulated in lethally compared to sublethally dosed mice. Of note, many of the greatest up- and downregulated miRNAs, namely 574-5 p, 466 g, 466 f-3p, 375, 29 c, and 148 a, have …
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
United States Department of Agriculture Wildlife Services: Staff Publications
Brown treesnakes (Boiga irregularis) are an invasive species to the island of Guam. Because they have extirpated the native forest avifauna on Guam and are a threat to other Pacific islands, the development of efficient and cost-effective methods to control them is desired. We compared the efficacy, cost, and effort required to remove brown treesnakes on 6-ha plots in forest scrub on Guam, using 2 methods: trapping and poison baiting. Toxic baits consisted of dead neonatal mice adulterated with 80-mg acetaminophen. To assess efficacy, we used mark-recapture methods to estimate snake abundance on plots 12 days before and …
Efficacy Of Aerial Broadcast Baiting In Reducing Brown Treesnake Numbers, Larry Clark, Peter J. Savarie
Efficacy Of Aerial Broadcast Baiting In Reducing Brown Treesnake Numbers, Larry Clark, Peter J. Savarie
United States Department of Agriculture Wildlife Services: Staff Publications
The brown treesnake (Boiga irregularis) is an invasive predator that was introduced on Guam as a stowaway in cargo after World War II. Since then, the population has exploded, attaining 50 to 100 snakes per ha in some areas. The snake has caused the extirpation of ten of the 12 native forest bird species on Guam. The U.S. Department of Agriculture, Wildlife Services, has a program to deter the spread of snakes from Guam to other islands. Hand capture from fences, trapping, toxic bait stations, and canine inspection of outbound cargo methods are used in the control program …
Physiologically-Based Pharmacokinetic Modeling Of Acetaminophen Metabolism And Toxicity, David M. Ng, Ali Navid
Physiologically-Based Pharmacokinetic Modeling Of Acetaminophen Metabolism And Toxicity, David M. Ng, Ali Navid
STAR Program Research Presentations
Acetaminophen is a common analgesic and antipyretic. Metabolism of acetaminophen and acetaminophen-induced liver necrosis are predicted using physiologically-based pharmacokinetic (PBPK) modeling. Pharmacokinetic means the model determines where the drug is distributed in the body over time. Physiologically-based means the anatomy and physiology of the human body is reflected in the structure and functioning of the model. Acetaminophen is usually safe and effective when taken as recommended, but consumption at higher levels may lead to liver damage. Additionally, other factors such as alcoholic liver disease, smoking, and malnutrition affect the maximum safe dose of acetaminophen.
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
Brian S Dorr
Abstract: Brown treesnakes (Boiga irregularis) are an invasive species to the island of Guam. Because they have extirpated the native forest avifauna on Guam and are a threat to other Pacific islands, the development of efficient and cost-effective methods to control them is desired. We compared the efficacy, cost, and effort required to remove brown treesnakes on 6-ha plots in forest scrub on Guam, using 2 methods: trapping and poison baiting. Toxic baits consisted of dead neonatal mice adulterated with 80-mg acetaminophen. To assess efficacy, we used mark-recapture methods to estimate snake abundance on plots 12 days before and 12 …
Efficacy Of Aerial Broadcast Baiting In Reducing Brown Treesnake Numbers, Larry Clark, Peter J. Savarie
Efficacy Of Aerial Broadcast Baiting In Reducing Brown Treesnake Numbers, Larry Clark, Peter J. Savarie
Human–Wildlife Interactions
The brown treesnake (Boiga irregularis) is an invasive predator that was introduced on Guam as a stowaway in cargo after World War II. Since then, the population has exploded, attaining 50 to 100 snakes per ha in some areas. The snake has caused the extirpation of ten of the 12 native forest bird species on Guam. The U.S. Department of Agriculture, Wildlife Services, has a program to deter the spread of snakes from Guam to other islands. Hand capture from fences, trapping, toxic bait stations, and canine inspection of outbound cargo methods are used in the control program …
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
Efficacy, Effort, And Cost Comparisons Of Trapping And Acetaminophen-Baiting For Control Of Brown Treesnakes On Guam, Larry Clark, Peter J. Savarie, John A. Shivik, Stewart W. Breck, Brian S. Dorr
Human–Wildlife Interactions
Brown treesnakes (Boiga irregularis) are an invasive species to the island of Guam. Because they have extirpated the native forest avifauna on Guam and are a threat to other Pacific islands, the development of efficient and cost-effective methods to control them is desired. We compared the efficacy, cost, and effort required to remove brown treesnakes on 6-ha plots in forest scrub on Guam, using 2 methods: trapping and poison baiting. Toxic baits consisted of dead neonatal mice adulterated with 80-mg acetaminophen. To assess efficacy, we used mark-recapture methods to estimate snake abundance on plots 12 days before and 12 days …