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Full-Text Articles in Life Sciences
Anti-Invasive And Anti-Adhesive Activities Of A Recombinant Disintegrin, R-Viridistatin 2, Derived From The Prairie Rattlesnake (Crotalus Viridis Viridis), Sara E. Lucena, Ying Jia, Julio G. Soto, Jessica Parral, Esteban Cantu, Jeremy Brannon, Kristina Lardner, Carla J. Ramos, Agustin I. Seoane, Elda. E. Sánchez
Anti-Invasive And Anti-Adhesive Activities Of A Recombinant Disintegrin, R-Viridistatin 2, Derived From The Prairie Rattlesnake (Crotalus Viridis Viridis), Sara E. Lucena, Ying Jia, Julio G. Soto, Jessica Parral, Esteban Cantu, Jeremy Brannon, Kristina Lardner, Carla J. Ramos, Agustin I. Seoane, Elda. E. Sánchez
Biology Faculty Publications and Presentations
Snake venom disintegrins inhibit platelet aggregation and have anti-cancer activities. In this study, we report the cloning, expression, and functional activities of a recombinant disintegrin, r-viridistatin 2 (GenBank ID: JQ071899), from the Prairie rattlesnake. r-Viridistatin 2 was tested for anti-invasive and anti-adhesive activities against six different cancer cell lines (human urinary bladder carcinoma (T24), human fibrosarcoma (HT-1080), human skin melanoma (SK-Mel-28), human colorectal adenocarcinoma (CaCo-2), human breast adenocarcinoma (MDA-MB-231) and murine skin melanoma (B16F10)). r-Viridistatin 2 shares 96% and 64% amino acid identity with two other Prairie rattlesnake medium-sized disintegrins, viridin and viridistatin, respectively. r-Viridistatin 2 was able to …