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Determination Of Dna Methylation Levels At Specific Genomic Loci, Rebecca Garrett
Determination Of Dna Methylation Levels At Specific Genomic Loci, Rebecca Garrett
Senior Honors Theses
Alzheimer's disease is a devastating disease, affecting millions. There is some familial evidence of an inheritance pattern from a genetic basis in Alzheimer's disease patients, but even with revelation of the genetic linkage and genes associated with Alzheimer's disease, the inheritance pattern is too complicated to be properly explained. It is necessary to investigate other causes of the debilitating disease. To investigate further, the epigenome was studied - the regulation of the genome by methyl group addition.
To study the epigenome of an Alzheimer's disease-like state, isoschizomer enzymes were used to cleave CC*GG regions. Comparing the cleaved DNA sequences produced …