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Full-Text Articles in Life Sciences
Characterization Of The Role Nuclear Bmp2 (Nbmp2) Plays In Regulating Gene Expression, Fialka Grigorova
Characterization Of The Role Nuclear Bmp2 (Nbmp2) Plays In Regulating Gene Expression, Fialka Grigorova
Theses and Dissertations
The nBmp2 protein was first identified in a DNA affinity chromatography/mass spectrometry screen designed to detect proteins that interact with a cartilage-specific enhancer element (called D/E) from the type XI collagen gene Col11a2. The transcription factor SOX9, a protein from the Sox (SRY-related HMG box) family, binds to and activates gene expression from this enhancer. nBmp2 has no transcriptional activity of its own on this enhancer, but when co-transfected with SOX9 it increases SOX9's activation of D/E nearly 2-fold. SOX9 also activates cartilage-specific enhancer elements from the Col2a1, Col27a1, and Col9a1 genes. The purpose of this project …
Antioxidants In Cancer Research And Prevention: Assay Comparison, Structure-Function Analysis, And Food Product Analysis, Andrew Robert Garrett
Antioxidants In Cancer Research And Prevention: Assay Comparison, Structure-Function Analysis, And Food Product Analysis, Andrew Robert Garrett
Theses and Dissertations
Recent epidemiological studies have suggested that the development and progression of several chronic diseases may be initiated or augmented by oxidative stress. Reactive oxygen species and reactive nitrogen species react readily with and can damage nucleic acids, proteins, and lipids. While biological systems are equipped antioxidant defenses to cope with oxidative stress, oxidative damage may still occur when oxidative stress overwhelms antioxidant defenses. This damage, if left unchecked, may lead to a variety of degenerative diseases, including heart disease, Alzheimer's Disease, Parkinson's Disease and cancer. Several assays have been designed to describe the antioxidant activity of various phytochemicals, vitamins, and …