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Ex Vivo Drug Sensitivity Of Malaria Parasites Under Selective Pressure In Tororo, Uganda, P. K. Tumebaze, O. Byaruhanga, J. Okiring, S. L. Nsobya, R. A. Cooper, P. J. Rosenthal
Ex Vivo Drug Sensitivity Of Malaria Parasites Under Selective Pressure In Tororo, Uganda, P. K. Tumebaze, O. Byaruhanga, J. Okiring, S. L. Nsobya, R. A. Cooper, P. J. Rosenthal
Roland A. Cooper
Artemisinin-based combination therapies (ACTs) are standard treatments for uncomplicated malaria in Africa. ACTs provide highly effective treatment, and regular use may offer protection against malaria in high risk populations. However, increased use of ACTs may select for parasites with decreased sensitivity. We studied the ex vivo sensitivity of malaria parasites collected from children enrolled in treatment and prevention trials in Tororo, Uganda from June, 2010 to August, 2011. When P. falciparum malaria was diagnosed, blood was obtained, parasites were cultured with serial dilutions of chloroquine (CQ), monodesethylamodiaquine (AQ), quinine (QN), dihydroartemisinin (DHA), lumefantrine (LM), and piperaquine (PQ) for 72 hours, …