Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 9 of 9

Full-Text Articles in Life Sciences

Genome-Scale Dynamics Modeling Of The Competition Between Rhodoferax And Geobacter In Anoxic Subsurface Environments, Derek Lovley, Kai Zhuang, Mounir Izallalen, Paula Museor, Hanno Richter, Carla Risso, Radhakrishnan Mahadevan Apr 2012

Genome-Scale Dynamics Modeling Of The Competition Between Rhodoferax And Geobacter In Anoxic Subsurface Environments, Derek Lovley, Kai Zhuang, Mounir Izallalen, Paula Museor, Hanno Richter, Carla Risso, Radhakrishnan Mahadevan

Carla Risso

The advent of rapid complete genome sequencing, and the potential to capture this information in genome-scale metabolic models, provide the possibility of comprehensively modeling microbial community interactions. For example, Rhodoferax and Geobacter species are acetate-oxidizing Fe(III)-reducers that compete in anoxic subsurface environments and this competition may have an influence on the in situ bioremediation of uranium-contaminated groundwater. Therefore, genome-scale models of Geobacter sulfurreducens and Rhodoferax ferrireducens were used to evaluate how Geobacter and Rhodoferax species might compete under diverse conditions found in a uranium-contaminated aquifer in Rifle, CO. The model predicted that at the low rates of acetate flux expected …


Ex Vivo Drug Sensitivity Of Malaria Parasites Under Selective Pressure In Tororo, Uganda, P. K. Tumebaze, O. Byaruhanga, J. Okiring, S. L. Nsobya, R. A. Cooper, P. J. Rosenthal Nov 2011

Ex Vivo Drug Sensitivity Of Malaria Parasites Under Selective Pressure In Tororo, Uganda, P. K. Tumebaze, O. Byaruhanga, J. Okiring, S. L. Nsobya, R. A. Cooper, P. J. Rosenthal

Roland A. Cooper

Artemisinin-based combination therapies (ACTs) are standard treatments for uncomplicated malaria in Africa. ACTs provide highly effective treatment, and regular use may offer protection against malaria in high risk populations. However, increased use of ACTs may select for parasites with decreased sensitivity. We studied the ex vivo sensitivity of malaria parasites collected from children enrolled in treatment and prevention trials in Tororo, Uganda from June, 2010 to August, 2011. When P. falciparum malaria was diagnosed, blood was obtained, parasites were cultured with serial dilutions of chloroquine (CQ), monodesethylamodiaquine (AQ), quinine (QN), dihydroartemisinin (DHA), lumefantrine (LM), and piperaquine (PQ) for 72 hours, …


Sunscreen Biosynthesis In Cyanobacteria, Tanya Soule Aug 2011

Sunscreen Biosynthesis In Cyanobacteria, Tanya Soule

Tanya Soule

No abstract provided.


Mexican Axolotls ( Ambystoma Mexicanum ) Appear To Be Resistant To Ambystoma Tigrinum Virus (Atv), Crystal Paulson, Robert Visalli, Mark Jordan Jul 2011

Mexican Axolotls ( Ambystoma Mexicanum ) Appear To Be Resistant To Ambystoma Tigrinum Virus (Atv), Crystal Paulson, Robert Visalli, Mark Jordan

Mark A. Jordan

No abstract provided.


Molecular Anatomy Of The Developing Limb In The Coqu ́I Frog, Eleutherodactylus Coqui, Joshua Gross, Ryan Kerney, James Hanken, Clifford Tabin Dec 2010

Molecular Anatomy Of The Developing Limb In The Coqu ́I Frog, Eleutherodactylus Coqui, Joshua Gross, Ryan Kerney, James Hanken, Clifford Tabin

Ryan Kerney

The vertebrate limb demonstrates remark- able similarity in basic organization across phylogenetically disparate groups. To gain further insight into how this mor- phological similarity is maintained in different developmental contexts, we explored the molecular anatomy of size-reduced embryos of the Puerto Rican coqu ́ı frog, Eleutherodactylus coqui. This animal demonstrates direct development, a life- history strategy marked by rapid progression from egg to adult and absence of a free-living, aquatic larva. Nonethe- less, coqu ́ı exhibits a basal anuran limb structure, with four toes on the forelimb and five toes on the hind limb. We in- vestigated the extent to …


Levels Of Biological Organization And The Origin Of Novelty, Brian Hall, Ryan Kerney Dec 2010

Levels Of Biological Organization And The Origin Of Novelty, Brian Hall, Ryan Kerney

Ryan Kerney

The concept of novelty in evolutionary biology pertains to multiple tiers of biological organization from behavioral and morphological changes to changes at the molecular level. Identifying novel features requires assessments of similarity (homology and homoplasy) of relationships (phylogenetic history) and of shared developmental and genetic pathways or networks. After a brief discussion of how novelty is used in recent literature, we discuss whether the evolutionary approach to homology and homoplasy initially formulated by Lankester in the 19th century informs our understanding of novelty today. We then discuss six examples of morphological features described in the recent literature as novelties, and …


Embryonic Staging Table For A Direct- Developing Salamander, Plethodon Cinereus (Plethodontidae), Ryan Kerney Dec 2010

Embryonic Staging Table For A Direct- Developing Salamander, Plethodon Cinereus (Plethodontidae), Ryan Kerney

Ryan Kerney

This work presents a refined staging table for the direct-developing red-backed salamander Plethodon cinereus, which is based on the incom- plete staging system of James Norman Dent (J Morphol 1942; 71:577– 601). This common species from eastern North America is a member of the species-rich lungless salamander family Plethodontidae. The stag- ing table presented here covers several stages omitted by Dent and reveals novel developmental features of P. cinereus embryos. These include putative Leydig cells and open gill clefts, which are found in lar- vae of metamorphosing species but were previously reported as absent in direct-developing Plethodon. Other features found …


Are Species Cohesive?—A View From Bacteriology, Frederick M. Cohan Dec 2010

Are Species Cohesive?—A View From Bacteriology, Frederick M. Cohan

Frederick M. Cohan

No abstract provided.


Q&A: Frederick Cohan Dec 2010

Q&A: Frederick Cohan

Frederick M. Cohan

No abstract provided.