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Differential Localization Of Icsa And Icsp In The Outer Membrane Of Shigella Flexneri, Robin Herlands, Helen Wing
Differential Localization Of Icsa And Icsp In The Outer Membrane Of Shigella Flexneri, Robin Herlands, Helen Wing
Undergraduate Research Opportunities Program (UROP)
Our goal is to visualize IcsP on the surface of S. flexneri and determine how its localization changes during growth versus stationary phases. We hypothesize IcsP will be present on the surface of S. flexneri differentially during growth and stationary phases of cell cycle. We hypothesize greater levels of IcsP seen during stationary phase (simultaneous with lower, more unipolar IcsA, due to IcsP mediated cleavage). During growth phase, we expect less IcsP to be present on the surface, and IcsA to be more evenly distributed around the cell surface.
The Regulation Of The Icsp Promoter Of Shigella Flexneri By Ryhb, Lia A. Africa, Helen J. Wing
The Regulation Of The Icsp Promoter Of Shigella Flexneri By Ryhb, Lia A. Africa, Helen J. Wing
Undergraduate Research Opportunities Program (UROP)
Iron is an essential element in the metabolism of many organisms, including bacteria. In many pathogenic bacteria, the levels of iron present trigger the expression of many virulence genes. In Shigella, a gram-negative bacterium that causes dysentery in humans, the expression of a small regulatory RNA, ryhB, is blocked in the presence of iron. Studies have revealed that ryhB represses virB, a global regulator of virulence genes in Shigella.
The icsP gene is under the direct control of VirB. icsP encodes an outer membrane protease that cleaves a protein necessary for the actin tail assembly of Shigella in vitro. In …
Survival Of Shigella Flexneri In Swimming Pool Water, Monique Gomez, Helen J. Wing
Survival Of Shigella Flexneri In Swimming Pool Water, Monique Gomez, Helen J. Wing
Undergraduate Research Opportunities Program (UROP)
Shigellosis is a disease caused by the pathogenic bacterium Shigella flexneri. The bacterium causes bloody diarrheadiarrhea, fever and abdominal pain. Infections can be and may cause fatal. . The disease may also cause bloody diarrhea and intense intestinal crampings. In the United States, there have been many outbreaks of shigellosis have been traced back to associated with inadequately disinfectedchlorinated public swimming pools and wading pools. These outbreaks of sShigellosis are most commonly seen among small children who play in these pools. . My goal is to determine how well Shigella survives in freshly chlorinated pool water and in pool water …