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The Effects Of Prenatal Exposure Of Valproic Acid On Cranial Nerve Nuclei: A Rat Model For An Autistic Phenotype, Shannon Pickup

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Autistic spectrum disorder is a term referring to five pervasive developmental disorders characterized by impairment in social interaction, deficits in verbal and non-verbal communication and stereotyped repetitive behaviors and interests. The underlying brain injury that leads to autism is also unknown. The cause is also unknown but appears to be a combination of genetic and environmental factors. A study on prenatal thalidomide exposure found patients exposure on days 20-24 of gestation lead to a 1/3 rate of autism, a huge increase from the 1/150 rate of the general population. The thalidomide data suggests the initial injury leading to autism occurs …