Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Gnrh Immunocontraception Of Male And Female White-Tailed Deer Fawns, Lowell A. Miller, James P. Gionfriddo, Jack C. Rhyan, Kathleen A. Fagerstone, Donald C. Wagner, Gary J. Killian
Gnrh Immunocontraception Of Male And Female White-Tailed Deer Fawns, Lowell A. Miller, James P. Gionfriddo, Jack C. Rhyan, Kathleen A. Fagerstone, Donald C. Wagner, Gary J. Killian
Human–Wildlife Interactions
Immunocontraceptive vaccines based on gonadotropin-releasing hormone (GnRH) have been tested in adult white-tailed deer (Odocoileus virginianus), but their effects on fawns are unknown. The purpose of this study was to determine if early immunization against GnRH would induce a long-lasting immune response in fawns, and if it would delay or prevent sexual development. We gave primary and subsequent booster injections of a KLH-GnRH/Freund’s vaccine to 6 male and 6 female fawns. This vaccine contained the same active ingredients as GonaCon™ vaccine, but it contained Freund’s adjuvant instead of AdjuVac™ adjuvant. Two 450-μg injections were given 1 month apart …
Physiological Effects Of Gonadotropin-Releasing Hormone Immunocontraception On White-Tailed Deer, Paul D. Curtis, Milo E. Richmond, Lowell A. Miller, Fred W. Quimby
Physiological Effects Of Gonadotropin-Releasing Hormone Immunocontraception On White-Tailed Deer, Paul D. Curtis, Milo E. Richmond, Lowell A. Miller, Fred W. Quimby
Human–Wildlife Interactions
Before immunocontraceptives can be considered safe to use on wildlife species, potential health risks should be assessed. Gonadotropin-releasing hormone (GnRH) immunocontraceptive has successfully reduced fertility of white-tailed deer (Odocoileus virginianus); however, associated deer physiology has rarely been examined. We conducted gross necropsy examinations, histology, and blood chemistry comparisons on euthanized deer previously vaccinated with immunogenic GnRH (n = 18 females and n = 4 males), or left as untreated controls (n = 7 females and n = 6 males). Granulomas were found at injection sites of most deer, even 3 years post-treatment. There were no significant …