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Full-Text Articles in Life Sciences
Using A Literature-Based Nmf Model For Discovering Gene Functional Relationships, Elina Tjioe, Michael W. Berry, Ramin Homayouni, Kevin Heinrich
Using A Literature-Based Nmf Model For Discovering Gene Functional Relationships, Elina Tjioe, Michael W. Berry, Ramin Homayouni, Kevin Heinrich
Faculty Publications and Other Works -- General Biology
No abstract provided.
Differential Transferrin Expression In Placentae From Normal And Abnormal Pregnancies: A Pilot Study, Alena Kralova, Marta Svetlikova, Jindrich Madar, Zdena Ulcova-Gallova, Antonin Bukovsky, Jana Peknicova
Differential Transferrin Expression In Placentae From Normal And Abnormal Pregnancies: A Pilot Study, Alena Kralova, Marta Svetlikova, Jindrich Madar, Zdena Ulcova-Gallova, Antonin Bukovsky, Jana Peknicova
Faculty Publications and Other Works -- General Biology
Abstract
Background
The placenta is an important site for iron metabolism in humans. It transfers iron from the mother to the fetus. One of the major iron transport proteins is transferrin, which is a blood plasma protein crucial for iron uptake. Its localization and expression may be one of the markers to distinguish placental dysfunction.
Methods
In the experimental study we used antibody preparation, mass spectrometric analysis, biochemical and immunocytochemical methods for characterization of transferrin expression on the human choriocarcinoma cell line JAR (JAR cells), placental lysates, and cryostat sections. Newly designed monoclonal antibody TRO-tf-01 to human transferrin was applied …
Hybridization Produces Novelty When The Mapping Of Form To Function Is Many To One, Nicholas F. Parnell, C Darrin Hulsey, J. Todd Streelman
Hybridization Produces Novelty When The Mapping Of Form To Function Is Many To One, Nicholas F. Parnell, C Darrin Hulsey, J. Todd Streelman
Faculty Publications and Other Works -- General Biology
Background
Evolutionary biologists want to explain the origin of novel features and functions. Two recent but separate lines of research address this question. The first describes one possible outcome of hybridization, called transgressive segregation, where hybrid offspring exhibit trait distributions outside of the parental range. The second considers the explicit mapping of form to function and illustrates manifold paths to similar function (called many to one mapping, MTOM) when the relationship between the two is complex. Under this scenario, functional novelty may be a product of the number of ways to elicit a functional outcome (i.e., the degree of MTOM). …