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Full-Text Articles in Life Sciences
Gene Signature Of Stromal Cells Which Support Dendritic Cell Development., Geneviève Despars, Pravin Periasamy, Jonathan Tan, Janice Abbey, Terence O'Neill, Helen O'Neill
Gene Signature Of Stromal Cells Which Support Dendritic Cell Development., Geneviève Despars, Pravin Periasamy, Jonathan Tan, Janice Abbey, Terence O'Neill, Helen O'Neill
Jonathan Tan
Spleen stromal cells are critical determinants of dendritic cell (DC) development in spleen. The spleen stromal line, namely STX3, supports DC differentiation in vitro from overlaid bone marrow cells while the lymph node stromal line, namely 2RL22, does not. Here we have characterised the hematopoietic support capacity of each stroma, and analyzed lineage origin of the stromal cell lines by gene profiling using microarrays. Stromal co-culture experiments were performed using bone marrow cells as a source of hematopoietic progenitors. A characteristic immature myeloid-like CD11c+CD11b+CD86+MHC-II−/loB220−CD8α− DC is produced after 14 days in STX3 cocultures, while 2RL22 cocultures produce only monocyte/macrophage-like cells. …
Alfred Russel Wallace, Journalist, Charles H. Smith
Alfred Russel Wallace, Journalist, Charles H. Smith
Charles Kay Smith
No abstract provided.
Flexible Filamentous Virus Structures From Fiber Diffraction, Gerald Stubbs, Amy Kendall, Michele Mcdonald, Wen Bian, Timothy Bowles, Sarah Baumgarten, Ian Mccullough, Jian Shi, Phoebe Stewart, Esther Bullitt, David Gore, Said Ghabrial
Flexible Filamentous Virus Structures From Fiber Diffraction, Gerald Stubbs, Amy Kendall, Michele Mcdonald, Wen Bian, Timothy Bowles, Sarah Baumgarten, Ian Mccullough, Jian Shi, Phoebe Stewart, Esther Bullitt, David Gore, Said Ghabrial
Ian McCullough
Fiber diffraction data have been obtained from Narcissus mosaic virus, a potexvirus from the family Flexiviridae, and soybean mosaic virus (SMV), a potyvirus from the family Potyviridae. Analysis of the data in conjunction with cryo-electron microscopy data allowed us to determine the symmetry of the viruses and to make reconstructions of SMV at 19 Å resolution and of another potexvirus, papaya mosaic virus, at 18 Å resolution. These data include the first well-ordered data ever obtained for the potyviruses and the best-ordered data from the potexviruses, and offer the promise of eventual high resolution structure determinations.
Identifying The Fundamental Units Of Bacterial Diversity: A Paradigm Shift To Incorporate Ecology Into Bacterial Systematics, A. F. Koeppel, E. B. Perry, J. Sikorski, A. Warner, D. M. Ward, A. P. Rooney, E. Brambilla, N. Connor, E. Nevo, R. M. Ratcliff, Frederick M. Cohan
Identifying The Fundamental Units Of Bacterial Diversity: A Paradigm Shift To Incorporate Ecology Into Bacterial Systematics, A. F. Koeppel, E. B. Perry, J. Sikorski, A. Warner, D. M. Ward, A. P. Rooney, E. Brambilla, N. Connor, E. Nevo, R. M. Ratcliff, Frederick M. Cohan
Frederick M. Cohan
No abstract provided.