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Avpv Neurons Containing Estrogen Receptor-Beta In Adult Male Rats Are Influenced By Soy Isoflavones, Edwin D. Lephart, Lihong H. Bu
Avpv Neurons Containing Estrogen Receptor-Beta In Adult Male Rats Are Influenced By Soy Isoflavones, Edwin D. Lephart, Lihong H. Bu
Faculty Publications
Background Isoflavones, the most abundant phytoestrogens in soy foods, are structurally similar to 17beta-estradiol. It is known that 17beta-estradiol induces apoptosis in anteroventral periventricular nucleus (AVPV) in rat brain. Also, there is evidence that consumption of soy isoflavones reduces the volume of AVPV in male rats. Therefore, in this study, we examined the influence of dietary soy isoflavones on apoptosis in AVPV of 150 day-old male rats fed either a soy isoflavone-free diet (Phyto-free) or a soy isoflavone-rich diet (Phyto-600). Results: The occurrence of apoptosis in AVPV was examined by TUNEL staining. The incidence of apoptosis was about 10 times …