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Full-Text Articles in Life Sciences
Inhibitory Effects Of Estrogen Receptor Beta On Specific Hormone-Responsive Gene Expression And Association With Disease Outcome In Primary Breast Cancer, Chin-Yo Lin, Anders Strom, Li Say Kong, Silke Kietz, Jane S. Thomsen, Jason B. S. Tee, Vinsensius B. Vega, Lance D. Miller, Johanna Smeds, Jonas Bergh, Jan-Ake Gustafsson, Edison T. Liu
Inhibitory Effects Of Estrogen Receptor Beta On Specific Hormone-Responsive Gene Expression And Association With Disease Outcome In Primary Breast Cancer, Chin-Yo Lin, Anders Strom, Li Say Kong, Silke Kietz, Jane S. Thomsen, Jason B. S. Tee, Vinsensius B. Vega, Lance D. Miller, Johanna Smeds, Jonas Bergh, Jan-Ake Gustafsson, Edison T. Liu
Faculty Publications
The impact of interactions between the two estrogen receptor (ER) subtypes, ER(alpha) and ER(beta), on gene expression in breast cancer biology is not clear. The goal of this study was to examine transcriptomic alterations in cancer cells co-expressing both receptors and the association of gene expression signatures with disease outcome. Methods: Transcriptional effects of ER(beta) overexpression were determined in a stably transfected cell line derived from ER(alpha) -positive T-47D cells. Microarray analysis was carried out to identify differential gene expression in the cell line, and expression of key genes was validated by quantitative polymerase chain reaction. Microarray and clinical data …