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Behavioral Aspects Of Apolipoprotein E Knockout Mice, Melissa T. Litherland

Masters Theses

Apolipoprotein E (apoE) is a lipid transporting protein that has been shown to play a vital role in nerve repair and remodeling. Previous studies have shown that apoE is highly expressed in human and mouse olfactory bulbs. ApoE deficiency in apolipoprotein E knockout (apoE-KO) mice leads to considerable delay in olfactory nerve repair and deficits in olfactory functioning. Olfactory function is necessary for a number of social behaviors in mice. Loss of olfaction can greatly reduce social behaviors. Since apoE-KO mice display olfactory dysfunction, this deficit may result in alterations in social behavior. Olfactory function was assessed in apoE-KO mice …