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2003

Conference on Applied Statistics in Agriculture

Fieller's

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Quadratic Model To Estimate The Doses Causing The Highest Cholesterol Concentration And The Same Cholesterol Concentration As Control Group, Wuyan Zhang, Steve Nissen, Donald Beitz, Philip Dixon Apr 2003

Quadratic Model To Estimate The Doses Causing The Highest Cholesterol Concentration And The Same Cholesterol Concentration As Control Group, Wuyan Zhang, Steve Nissen, Donald Beitz, Philip Dixon

Conference on Applied Statistics in Agriculture

High plasma cholesterol (particularly high LDL-cholesterol) is a high risk factor for coronary heart disease (CHD), which causes a high CHD morbidity and mortality. Besides clinical drugs, more and more interest is focused on finding natural components in the diet that may have hypocholesterolemic effects. Plant sterols are natural components in human diets and found to have cholesterol-lowering effects in humans. Sheanut oil has a relatively high amolmt of plant sterols. Therefore, the two experiments were designed to investigate the hypocholesterolemic effect of sheanut oil in hamsters. The response was not monotonic. Low doses increased plasma cholesterol, but high doses …