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Circadian rhythms; suprachiasmatic nucleus; polysialic acid; NCAM; phase-shift; glutamate; endoneuraminidase
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Intrinsic Role Of Polysialylated Neural Cell Adhesion Molecule In Photic Phase Resetting Of The Mammalian Circadian Clock, Rebecca Prosser
Intrinsic Role Of Polysialylated Neural Cell Adhesion Molecule In Photic Phase Resetting Of The Mammalian Circadian Clock, Rebecca Prosser
Rebecca Prosser
The suprachiasmatic nuclei (SCN), the location of the mammalian circadian clock, are one of the few adult brain regions that express the highly polysialylated form of neural cell adhesion molecule (PSA-NCAM). A role for the polysialic acid (PSA) component of PSA-NCAM, which is known to promote tissue plasticity, has been reported for photic entrainment of circadian rhythmicity in vivo. The in vivo results, however, do not discriminate between PSA acting upstream or downstream of the glutamatergic synapses that convey photic information to the SCN. To address this key issue, we exploited an in vitro rat brain slice preparation that retains …