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Full-Text Articles in Life Sciences
Mhc Class I Molecules And Progression To Aids, Mary Carrington, Xiaojiang Gao, Stephen J. O'Brien
Mhc Class I Molecules And Progression To Aids, Mary Carrington, Xiaojiang Gao, Stephen J. O'Brien
Biology Faculty Articles
No abstract provided.
Effect Of A Single Amino Acid Change In Mhc Class I Molecules On The Rate Of Progression To Aids, Xiaojiang Gao, George W. Nelson, Peter Karacki, Maureen P. Martin, John Phair, Richard A. Kaslow, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J. O'Brien, Mary Carrington
Effect Of A Single Amino Acid Change In Mhc Class I Molecules On The Rate Of Progression To Aids, Xiaojiang Gao, George W. Nelson, Peter Karacki, Maureen P. Martin, John Phair, Richard A. Kaslow, James J. Goedert, Susan Buchbinder, Keith Hoots, David Vlahov, Stephen J. O'Brien, Mary Carrington
Biology Faculty Articles
Background From studies of genetic polymorphisms and the rate of progression from human immunodeficiency virus type 1 (HIV-1) infection to the acquired immunodeficiency syndrome (AIDS), it appears that the strongest susceptibility is conferred by the major-histocompatibility-complex (MHC) class I type HLA-B*35,Cw*04 allele. However, cytotoxic T-lymphocyte responses have been observed against HIV-1 epitopes presented by HLA-B*3501, the most common HLA-B*35 subtype. We examined subtypes of HLA-B*35 in five cohorts and analyzed the relation of structural differences between HLA-B*35 subtypes to the risk of progression to AIDS. Methods Genotyping of HLA class I loci was performed for 850 patients who seroconverted and …