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Life Sciences Commons™

Open Access. Powered by Scholars. Published by Universities.®

2000

Physical Sciences and Mathematics

Selected Works

Articles 1 - 6 of 6

Full-Text Articles in Life Sciences

Relationship Of Molecular Structure To The Mechanism Of Lysophospholipid-Induced Smooth Muscle Cell Proliferation, Yuh-Cherng Chai, David Binion, Guy Chisholm Sep 2000

Relationship Of Molecular Structure To The Mechanism Of Lysophospholipid-Induced Smooth Muscle Cell Proliferation, Yuh-Cherng Chai, David Binion, Guy Chisholm

Yuh-Cherng Chai

No abstract provided.

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Clusterin Is An Atp-Independent Chaperone With Very Broad Substrate Specificity That Stabilizes Stressed Proteins In A Folding-Competent State, Stephen Poon, Simon Easterbrook-Smith, Mark Rybchyn, John Carver, Mark Wilson Dec 1999

Clusterin Is An Atp-Independent Chaperone With Very Broad Substrate Specificity That Stabilizes Stressed Proteins In A Folding-Competent State, Stephen Poon, Simon Easterbrook-Smith, Mark Rybchyn, John Carver, Mark Wilson

Mark R Wilson

We recently reported that the ubiquitous, secreted protein clusterin has chaperone activity in vitro [Humphreys et al. (1999) J. Biol. Chem. 274, 6875−6881]. In this study, we demonstrate that clusterin (i) inhibits stress-induced precipitation of a very broad range of structurally divergent protein substrates, (ii) binds irreversibly via an ATP-independent mechanism to stressed proteins to form solubilized high molecular weight complexes, (iii) lacks detectable ATPase activity, (iv) when acting alone, does not effect refolding of stressed proteins in vitro, and (v) stabilizes stressed proteins in a state competent for refolding by heat shock protein 70 (HSP70). Furthermore, we show that, …

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Collaborative Activity Between Parietal And Dorso-Lateral Prefrontal Cortex In Dynamic Spatial Working Memory Revealed By Fmri, Vaibhav A. Diwadkar, Patricia A. Carpenter, Marcel Adam Just Dec 1999

Collaborative Activity Between Parietal And Dorso-Lateral Prefrontal Cortex In Dynamic Spatial Working Memory Revealed By Fmri, Vaibhav A. Diwadkar, Patricia A. Carpenter, Marcel Adam Just

Marcel Adam Just

No abstract provided.

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The Neural Basis Of Strategy And Skill In Sentence-Picture Verification, Erik D. Reichle, Patricia A. A. Carpenter, Marcel Adam Just Dec 1999

The Neural Basis Of Strategy And Skill In Sentence-Picture Verification, Erik D. Reichle, Patricia A. A. Carpenter, Marcel Adam Just

Marcel Adam Just

No abstract provided.

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Working Memory And Executive Function: Evidence From Neuroimaging, Patricia A. Carpenter, Marcel Adam Just, Erik D. Reichle Dec 1999

Working Memory And Executive Function: Evidence From Neuroimaging, Patricia A. Carpenter, Marcel Adam Just, Erik D. Reichle

Marcel Adam Just

No abstract provided.

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Reflexive Autopoietic Systems Theory, Kent D. Palmer Dec 1999

Reflexive Autopoietic Systems Theory, Kent D. Palmer

Kent D. Palmer

Exploring the Meta-systems of Emergent Worlds

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