Life Sciences Commons^™

Mechanisms Of Cytokine-Mediated Localized Immunoprotection., Nora Sarvetnick

Journal Articles: Regenerative Medicine

No abstract provided.

Pancreatic Expression Of Interleukin-4 Abrogates Insulitis And Autoimmune Diabetes In Nonobese Diabetic (Nod) Mice., Regula Mueller, Troy Krahl, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Diabetes in nonobese diabetic (NOD) mice is a T cell-dependent autoimmune disease. The destructive activities of autoreactive T cells have been shown to be tightly regulated by effector molecules. In particular, T helper (Th) 1 cytokines have been linked to diabetes pathogenesis, whereas Th2 cytokines and the cells that release them have been postulated to be protective from disease. To test this hypothesis, we generated transgenic NOD mice that express interleukin (IL) 4 in their pancreatic beta cells under the control of the human insulin promoter. We found that transgenic NOD-IL-4 mice, both females and males, were completely protected from …

Il-10 Is Necessary And Sufficient For Autoimmune Diabetes In Conjunction With Nod Mhc Homozygosity., Myung-Shik Lee, Regula Mueller, Linda S. Wicker, Laurence B. Peterson, Nora Sarvetnick

Journal Articles: Regenerative Medicine

Contrary to expectations based on in vitro experiments, we previously found that pancreatic IL-10 did not inhibit autoimmune diabetes but accelerated it in an MHC-dependent manner. Therefore, the ability of IL-10 to overcome the absence of all non-MHC diabetes susceptibility (Idd) alleles was studied in transgenic mice expressing pancreatic IL-10 backcrossed to B10.H2g7 congenic mice, which have no Idd alleles other than NOD MHC (H2g7). IL-10 transgenic backcross 1 (BC1) mice with H2g7/g7 haplotype developed clear-cut insulitis and diabetes, but neither transgenic mice with the H2g/b haplotype nor nontransgenic BC1 mice did so. Further implicating IL-10 in autoimmune diabetes, anti-IL-10 …

Anion Induced Blue To Purple Transition In Bacteriorhodopsin, Mrunalini Pattarkine, Anil K. Singh

Faculty Works

Purple membrane (PM, λ" role="presentation">λmax" role="presentation">max 570 nm) of H. halobium on treatment with sulphuric acid changes its colour to blue (λ" role="presentation">λmax" role="presentation">max 608 nm). The purple chromophore can be regenerated from the blue chromophore by exogeneous addition of anions such as CI−" role="presentation">− and HPO42−" role="presentation">2−4. Chloride ion is found to be more effective than the dibasic phosphate ion in regenerating the purple chromophore. Nevertheless, one thing common to the anion regeneration is that both CI−" role="presentation">− and HPO42−" role="presentation">2−4 show marked pH effect. At pH 1.0 the efficiency of …

Vegetative Filter Strip Design For Grassed Areas Treated With Animal Manures, Dwayne R. Edwards, Tommy C. Daniel, Philip A. Moore Jr.

Biosystems and Agricultural Engineering Faculty Publications

Vegetative filter strips (VFS) are a low-cost management option that have been demonstrated to be effective in reducing runoff transport of fertilizer constituents applied to grassed areas (pasture or meadow). Runoff quality studies involving fertilizers applied to grassed areas suggest that VFS can be designed by assuming that (1) only infiltration is responsible for pollutant removal, (2) the first post-application runoff event is most important from a water quality perspective (enabling a design event approach), and (3) no pollutant build-up that degrades VFS performance will occur. The purpose of this study was to develop a VFS design algorithm for grassed …

Poultry Litter-Treated Length Effects On Quality Of Runoff From Fescue Plots, Dwayne R. Edwards, Philip A. Moore Jr., Tommy C. Daniel, Puneet Srivastava

Biosystems and Agricultural Engineering Faculty Publications

Using experimental data and/or mathematical simulation models to identify practices that reduce pollution from manure-treated areas is sometimes perceived as limited by the unknown validity of extrapolating plot-scale data to larger areas and by uncertainties in modeling transport of various pollutants. The objectives of this study were to assess the effect of length of manure treatment on runoff concentrations of poultry litter constituents and to define the modes of transport (particulate versus soluble) for nitrogen (N), phosphorus (P), carbon (C), and solids. Poultry litter was applied to three 1.5- x 18.3-m fescue (Festuca arundinacea Schreb.) plots with runoff collection …

Quality Of Runoff From Four Northwest Arkansas Pasture Fields Treated With Organic And Inorganic Fertilizer, Dwayne R. Edwards, Tommy C. Daniel, John F. Murdoch, Philip A. Moore Jr.

Biosystems and Agricultural Engineering Faculty Publications

Long-term land application of animal manures, even at agronomic rates, can promote accumulation of soil phosphorus (P) which can, in turn, contribute to increased P loadings to downstream waters. The objective of this study was to assess the soil and runoff effects of replacing animal manure as a soil amendment with inorganic fertilizer (ammonium nitrate, NH₄NO₃) on fields that had been treated previously with animal manures. Runoff from two pairs of small fields (0.57 to 1.46 ha) was sampled from September 1991 to April 1994. All fields had been treated previously with animal manures; after runoff …

Performance Of Vegetative Filter Strips With Varying Pollutant Source And Filter Strip Lengths, Puneet Srivastava, Dwayne R. Edwards, Tommy C. Daniel, Philip A. Moore Jr., Thomas A. Costello

Biosystems and Agricultural Engineering Faculty Publications

Vegetative filter strips (VFS) can reduce runoff losses of pollutants such as nitrogen (N) and phosphorus (P) from land areas treated with fertilizers. While VFS effectiveness is considered to depend on lengths of pollutant source and VFS areas, there is little experimental evidence of this dependence, particularly when the pollutant source is manure-treated pasture. This study assessed the effects of pollutant source area (fescue pasture treated with poultry litter) length and VFS (fescue pasture) length on VFS removal of nitrate N (NO₃-N), ammonia N (NH₃-N), total Kjeldahl N (TKN), ortho-P (PO₄-P), total P (TP), …

Simulation Of Runoff Transport Of Animal Manure Constituents, Yang Wang, Dwayne R. Edwards, Tommy C. Daniel, H. Don Scott

Biosystems and Agricultural Engineering Faculty Publications

Runoff losses of land-applied animal manure constituents can adversely affect the quality of downstream waters. Reliable mathematical simulation models can help estimate runoff losses of animal manure constituents and identify management measures to reduce these losses. The objective of this study was to develop and calibrate an event-based simulation model to describe the runoff transport of solids (soil and manure particles) and nutrients (nitrogen and phosphorus) from areas treated with animal manure. The resulting model, consisting of linked hydrology, soil/manure transport, and nutrient transport components, is process-oriented and uses measurable parameters to the greatest degree possible. The three components of …

A Direct, Approximate Solution To The Modified Green-Ampt Infiltration Equation, Puneet Srivastava, Thomas A. Costello, Dwayne R. Edwards

Biosystems and Agricultural Engineering Faculty Publications

Accurately predicting the rainfall-runoff process is of vital importance for water quality models as well as for correct design of various types of hydraulic structures. This article presents a method of describing the cumulative infiltration process as an explicit function of time using an approximation to the modified Green-Ampt equation given by Mein and Larson (1971). The resulting equation is helpful in predicting cumulative infiltration and therefore infiltration capacity for computer simulation models. The proposed method takes about 50% less time than the usual iterative technique for the same degree of accuracy. The maximum error due to approximation was 1% …

Development Of A Biologically Based Aerobic Composting Simulation Model, Dennis P. Stombaugh, Sue E. Nokes

Biosystems and Agricultural Engineering Faculty Publications

A relatively simple dynamic model based on microbial process kinetics has been developed for aerobic composting. Differential equations describing microbial, substrate, and oxygen concentrations, as well as moisture and temperature profiles have been derived as a function of vessel size and aeration rate. Microbial biomass growth was described using Monod growth kinetics as a function of degradable substrate concentration, oxygen concentration, moisture content, and compost temperature. Facility and fan operating costs have been included to permit economic optimization of the process. Predicted results demonstrated the ability of the model to quantify and describe the influence of multiple interacting factors (temperature, …

Minimum Ventilation For Modern Broiler Facilities, Richard S. Gates, Douglas G. Overhults, Shuhui H. Zhang

Biosystems and Agricultural Engineering Faculty Publications

New functions for whole-house broiler heat production as a function of bird age using modern straight run broiler growth rates are presented and compared to values in the literature. The approximations are based on field measurements of environmental conditions in modern broiler housing, using a technique that matches predicted to actual fuel use to estimate partitioning between latent and sensible heat. Development of a program utilizing these approximations to compute ventilation and heating requirements for temperature and humidity control in broiler housing is described. The program utilizes steady-state heat and moisture balances commonly used for design purposes, with hourly or …

Application Of Simplified Phosphorus Transport Models To Pasture Fields In Northwest Arkansas, Dwayne R. Edwards, C. T. Haan, Andrew N. Sharpley, John F. Murdoch, Tommy C. Daniel, Philip A. Moore Jr.

Biosystems and Agricultural Engineering Faculty Publications

Runoff transport of phosphorus (P) is often predicted from simple equations with parameters determined from data applicable primarily to row-cropped and fallow cover conditions. The applicability, accuracy, and precision of such P transport prediction equations under pasture situations are less well defined. The objectives of this study were to determine parameters of simplified runoff P transport equations for pasture fields and to assess the accuracy and precision of the equations. Runoff, sediment yield, soluble P transport, and particulate P transport data were collected from four pasture fields in northwestern Arkansas. Runoff event enrichment ratios and extraction coefficients were computed, and …

Evaluation Of The Crop Growth Component Of The Root Zone Water Quality Model For Corn In Ohio, Sue E. Nokes, Feliks M. Landa, Jon D. Hanson

Biosystems and Agricultural Engineering Faculty Publications

The Root Zone Water Quality Model (RZWQM) is a computer model developed to simulate water, chemical, and biological processes in the root zone of agricultural management systems. As of this writing RZWQM is in the beta-testing phase of development. This article reports on a parameterization and evaluation study performed in Ohio on field corn for the crop growth component of RZWQM. The generic crop growth model in RZWQM had not previously been parameterized or tested on field corn. This article reports the results of such a study. One year of data was used to calibrate RZWQM, and two additional years …

Comparison Of Daily Water Table Depth Prediction By Four Simulation Models, Eric D. Desmond, Andrew D. Ward, Norman R. Fausey, Stephen R. Workman

Biosystems and Agricultural Engineering Faculty Publications

The Agricultural Drainage And Pesticide Transport (ADAPT) model was compared to the water management simulation models DRAINMOD, SWATREN, and PREFLO. SWATREN and PREFLO are one-dimensional finite-difference models while ADAPT and DRAINMOD are one-dimensional mass balance models. ADAPT, an extension of the computer model GLEAMS, also provides chemical transport information. All four models were tested against field data from Aurora, North Carolina. Observed water table depth data were collected during 1973 through 1977 from a water table management field experiment with three subsurface drain spacing treatments of 7.5, 15, and 30 m.

Both the standard error of estimate and the average …

Quality Of Life Of Rural Nebraskans: How Are They Doing And What Is In The Future?, John C. Allen, Sam Cordes, Amy M. Smith, Matt Spilker, Amber Hamilton

Rural Futures Institute: Publications

Includes

Executive Summary

Introduction

Methodology and Respondent Profile

Findings

Global Well-Being

Change in the Modern World

Personal Well-Being

Availability of Services and Amenities

Dissatisfaction with Services and Amenities

Dissatisfaction with Services/Amenities by Region

Dissatisfaction with Services/Amenities by Community Size

Dissatisfaction with Services/Amenities by Income Level

Conclusions

Environmental Issues And Perceptions Of Rural Nebraskans, John C. Allen, Sam Cordes, Amy M. Smith, Mike Spilker, Amber Hamilton

Rural Futures Institute: Publications

Includes

Executive summary

Introduction

Methodology

Respondent profile

Findings

The State's Role in Groundwater Protection

Regulation and Compliance Costs

Agriculture and the Environment

Conjunctive Use

Conclusions

Nebraskan Work Patterns And Available Benefits, John C. Allen, Sam Cordes, Amy M. Smith, Matt Spilker, Amber Hamilton

Rural Futures Institute: Publications

Includes

Executive Summary

Introduction

Methodology

Respondent Profile

Findings

Nebraskans and Work

Rural Nebraskans and Benefits

Biology, Justice, And Women's Fate, Dorothy E. Roberts

All Faculty Scholarship

No abstract provided.