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Full-Text Articles in Life Sciences
Using Random Sequence Primers In The Polymerase Chain Reaction To Identify Gender-Specific Genetic Markers In House Wrens, Jeremy J. Kirchman '94
Using Random Sequence Primers In The Polymerase Chain Reaction To Identify Gender-Specific Genetic Markers In House Wrens, Jeremy J. Kirchman '94
Honors Projects
In order to fully understand the biology of asexually reproducing organism, it is essential that one is able to distinguish the males from the females. In determining the gender of monomorphic birds, standard techniques including visual identification, surgery, and karyotyping are impossible or impractical for large-scale studies. A reliable gender identification method that uses genetic markers identified within the DNA would be an asset to the researcher because it would require only a minimal blood sample which could be collected in the field without harming the bird and stored easily for long periods of time. Griffiths and Tiwari (1993) described …
Toward An Understanding Of Alzheimer's Disease: The Effects Of B-Amyloid(1-42) And Ibotenic Acid On The Retention Of A Spatial Learning Task In Rats F:Ollowing Multiple Injections Into The Hippocampus, Jason Pequette '94
Honors Projects
Neuropathologically, Alzheimer's disease (AD) is characterized by neuritic plaques and neurofibrillary tangles. Evidence has suggested that a protein called B-amyloid (BA) is a major component of the neuritic plaques and may playa role in the neurodegeneration seen in AD. The cellular mechanisms by which BA induces neurotoxicity, however, are still unclear. Recent evidence suggests that the aggregational state of BA may be relevant to its neurotoxicity. Whether portions of the BA protein or the entire sequence produces neurotoxicity in neurons, however, remains a controversy. Still another controversy is whether BA is directly neurotoxic to neurons or whether it increases the …