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Full-Text Articles in Life Sciences
Seizures And Brain Tumor In Neurologically Intact Adult Patients: Role Of Computerized Tomography (Ct Scan), Jamshid Seifi, Roushdy S. Boulos, Robert D. Teasdall
Seizures And Brain Tumor In Neurologically Intact Adult Patients: Role Of Computerized Tomography (Ct Scan), Jamshid Seifi, Roushdy S. Boulos, Robert D. Teasdall
Henry Ford Hospital Medical Journal
CT scan of 13 patients with adult onset of seizures who were neurologically intact and otherwise asymptomatic revealed a supratentorial mass in all. Significant EEG abnormalities were recorded in five, and the isotope brain scan was positive in eight. In three patients, both studies were normal. Angiograms confirmed the location of tumor, and histology was established following craniotomy. The value of the CT scan as a screening test for detecting brain tumor in this group of seizure patients is evident.
In Vitro And Clinical Studies Of Cefaclor, A New Cephalosporin, Daria Kiani, Tom Madhavan, Keith Burch, Don Pohlod, Evelyn Fisher, Edward L. Quinn
In Vitro And Clinical Studies Of Cefaclor, A New Cephalosporin, Daria Kiani, Tom Madhavan, Keith Burch, Don Pohlod, Evelyn Fisher, Edward L. Quinn
Henry Ford Hospital Medical Journal
In vitro susceptibility studies of 246 clinical isolates demonstrated that this antibiotic was effective against Group A beta hemolytic streptococci, alpha hemolytic streptococci, S. pneumoniae, both penicillinase producing and nonpenicillinase producing Staphylococci, Klebsiella pneumoniae, and Proteus mirabilis. Cephalothin susceptible E. coii were also susceptible to cefaclor. Pseudomonas aeruginosa, Serratia sp., Enterobacter Sp., and Streptococcus faecalis were uniformly resistant to cefaclor. The efficacy and safety of this antibiotic were studied in 27 patients with urinary tract, soft tissue, and respiratory infections. Patients with urinary tract infections became abacteriuric after 48 hours. Patients with soft tissue infections responded well within the first …
Endoscopic Retrograde Cholangiopancreatography At Henry Ford Hospital: 1972-1977, Bernard M. Schuman, Kian H. Wong, R. Salimi, A. N. Adham
Endoscopic Retrograde Cholangiopancreatography At Henry Ford Hospital: 1972-1977, Bernard M. Schuman, Kian H. Wong, R. Salimi, A. N. Adham
Henry Ford Hospital Medical Journal
Between 7972 and /977, 440 patients underwent endoscopic retrograde cholangiopancreatography (FRCP) at Henry Ford Hospital. The procedure was found to be most useful for identifying the site and nature of an extrahepatic obstruction, the diagnosis of pancreatic cancer, and the preoperative evaluation of chronic pancreatitis. One death occurred as a result of cholangitis in a patient with cancer of the pancreas. Review of the data has led us to refine our indications for FRCP. It has been shown to be a valuable technique with a low incidence of complications in evaluating pancreaticobiliary disease. Based on our study, it would be …
An Ischemic Infarct In Medulla And Cervical Cord, Ezzatollah Shivapour, Gilbert B. Solitare
An Ischemic Infarct In Medulla And Cervical Cord, Ezzatollah Shivapour, Gilbert B. Solitare
Henry Ford Hospital Medical Journal
This report documents an unusual case of an occlusion of the anterior spinal artery of the medulla oblongata. The patient presented with involvement of the left accessory nerve and weakness of ipsilateral extremities. The diagnosis of an ischemic infarct in the distribution of the left proximal portion of the anterior spinal artery was made. Bulbar weakness, quadriplegia, and respiratory arrest developed. Postmortem examination, 23 days after onset, revealed an old infarct in the medulla which appeared as a more recent hemorrhagic infarct throughout the cervical cord.
Mixed Connective Tissue Disease And Systemic Lupus Erythematosus In One Family, Michael R. Lubetsky, Howard Duncan
Mixed Connective Tissue Disease And Systemic Lupus Erythematosus In One Family, Michael R. Lubetsky, Howard Duncan
Henry Ford Hospital Medical Journal
A mother with mixed connective tissue disease (MCTD) and a daughter with systemic lupus erythematosus (SLE) were simultaneously diagnosed and treated in August, 1977. Multiple cases of SLE occurring in the same family are not rare, but the frequency with which systemic lupus erythematosus and mixed connective tissue disease occurs in the same family is not known, and the reports are few. This report describes these two cases and suggests that mixed connective tissue disease may be part of the spectrum of systemic lupus erythematosus.
Caloric Restriction And Bile Salt Dynamics In Intact And Cholecystectomized Syrian Hamsters, J. Sanfield, W. T. Beher, G. J. Lin, R. Haamen
Caloric Restriction And Bile Salt Dynamics In Intact And Cholecystectomized Syrian Hamsters, J. Sanfield, W. T. Beher, G. J. Lin, R. Haamen
Henry Ford Hospital Medical Journal
In vivo studies of bile salt absorption and distribution using 14C-taurocholate were made in fed and fasted, intact and cholecystectomized Syrian hamsters. There was no significant difference in the rate of ileal 14C-bile salt absorption or the distribution of 14C-bile salts among the compartments of the enterohepatic circulatory system in any of the animals. The results showed that the sphincter of Oddi is patent in fasting, intact and cholecystectomized hamsters. They also suggested that the diminished bile salt pool seen in fasted, cholecystectomized but not in intact hamsters arises from a) a primary, fasting-induced decrease in liver enzyme activity involved …
Clinical Notes: 201tl Chloride Uptake By Non-Hodgkins Lymphoma: Radiographic Exhibit, Daniel S. Marks, Keenan L. Carroll
Clinical Notes: 201tl Chloride Uptake By Non-Hodgkins Lymphoma: Radiographic Exhibit, Daniel S. Marks, Keenan L. Carroll
Henry Ford Hospital Medical Journal
This report describes intense uptake of 201Tl in a patient with histiocytic lymphoma. The activity seen was greater than with 67Ga. Use of 201Tl as an alternative imaging agent is advocated.
Expanded Polytetrafluoroethylene (Ptfe) And External Velour Grafts As Small Artery Substitutes In Dogs, Farouq Samhouri, Luis H. Toledo-Pereyra, Stanley G. Dienst, Roger F. Smith
Expanded Polytetrafluoroethylene (Ptfe) And External Velour Grafts As Small Artery Substitutes In Dogs, Farouq Samhouri, Luis H. Toledo-Pereyra, Stanley G. Dienst, Roger F. Smith
Henry Ford Hospital Medical Journal
This experimental study compared the clinical patency, angiographic appearance, and histology of 4 mm polytetrafluoroethylene (PTFE) and external double velour grafts which were used as external iliac artery substitutes in dogs. At one week there were no significant differences. However, at two months, none of the PTFE grafts were open, whereas six of the seven external double velour grafts were patent (p<0.05). Thus, in this study the 4 mm PTFE grafts are poor substitutes for canine iliac replacement.
Bone Erosion In Rheumatoid Arthritis, Howard Duncan, Catharina H. E. Mathews, Michael M. Crouch, A. M. Parfitt
Bone Erosion In Rheumatoid Arthritis, Howard Duncan, Catharina H. E. Mathews, Michael M. Crouch, A. M. Parfitt
Henry Ford Hospital Medical Journal
A histological study of fully mineralized bone sections was made on thirty joints surgically removed from patients with rheumatoid arthritis. The patterns of bone erosion fell into three groups: 1) that due to multinucleated osteoclasts; 2) areas of apparent bone erosion occupied exclusively by mononuclear cells; and 3) changes produced by an osteocyte which could either enlarge the lacuna space in which it resided or demineralize a region of bone in its immediate vicinity. Tissues taken from knee and hip specimens frequently showed all three cellular patterns of bone erosion, while the sections from finger joints rarely container multinucleated osteoclasts …
Scanning Electron Microscopy Of The Surface Of Human Duodenum In Patients With And Without Duodenal Ulcer Disease, Bernard M. Schuman, Klaus Ritter, John H. L. Watson, Jessica Goodwin
Scanning Electron Microscopy Of The Surface Of Human Duodenum In Patients With And Without Duodenal Ulcer Disease, Bernard M. Schuman, Klaus Ritter, John H. L. Watson, Jessica Goodwin
Henry Ford Hospital Medical Journal
Endoscopic biopsy specimens of normal human duodenum from patients with duodenal ulcer disease were studied by light microscopy and by scanning electron microscopy. For scanning, the tissue was dried by the critical point-drying technique. SEM criteria for both normal and abnormal duodenal surfaces were determined. SEM evidence for the presence of "tuft cells" similar to those found on the surface of rat duodenum was found in both the normal and abnormal human material. Although other reports have described the favorable effects of carbenoxolone sodium treatment on duodenal ulcer disease, our SEM studies of four patients found that this treatment had …
Common Sense And Surgical Research, Melvin A. Block
Common Sense And Surgical Research, Melvin A. Block
Henry Ford Hospital Medical Journal
No abstract provided.
Effect Of Acute Posttransplant Renal Failure On The Survival Of Perfused Cadaver Kidneys, Krishna D. Valjee, Luis H. Toledo-Pereyra, Stanley G. Dienst, Heung K. Oh, Daniel S. Marks, Pedro Cortes, Cosme Cruz, Godofredo Santiago, Nathan W. Levin
Effect Of Acute Posttransplant Renal Failure On The Survival Of Perfused Cadaver Kidneys, Krishna D. Valjee, Luis H. Toledo-Pereyra, Stanley G. Dienst, Heung K. Oh, Daniel S. Marks, Pedro Cortes, Cosme Cruz, Godofredo Santiago, Nathan W. Levin
Henry Ford Hospital Medical Journal
Between 7973 and 7977 we encountered 22 cases of acute renal failure after transplantation in 70 patients who received perfused cadaver kidneys. Nearly two-thirds of 76 nonfunctioning grafts were lost due to subsequent superimposed rejection, often undetected and, hence, untreated. Thirty-one percent of the 76 recovered function. The recovery rate, we believe, can be improved by earlier diagnosis and treatment of rejection and by avoiding invasive diagnostic procedures in the early postoperative period. If the oliguric period extends beyond two weeks, a closed percutaneous renal biopsy is justified. The diagnosis of rejection and/or other abnormality as well as subsequent treatment …
Effect Of Donor Pretreatment On The Graft Survival Of Human Cadaver Kidneys, Stanley G. Dienst, Krishna D. Valjee, Luis H. Toledo-Pereyra
Effect Of Donor Pretreatment On The Graft Survival Of Human Cadaver Kidneys, Stanley G. Dienst, Krishna D. Valjee, Luis H. Toledo-Pereyra
Henry Ford Hospital Medical Journal
The effect of donor pretreatment on perfused cadaver kidney allografts was evaluated in 40 recipients at Henry Ford Hospital over a two-year period. Ofthe 40,23 received kidneys from donors pretreated with 40 mg/K each of cyclophosphamide and methylprednisolone during the first year of the study and up to 70 mg/K during the second year. Our results indicated that donor pretreatment for five to eight hours did not consistently improve survival rates in pretreated perfused cadaver kidneys following transplantation. The use of cyclophosphamide for donor pretreatment does not prevent the use of continuous perfusion to preserve human kidneys. Dosages up to …
Radionuclide Evaluation Of Renal Transplant Patients, Daniel S. Marks
Radionuclide Evaluation Of Renal Transplant Patients, Daniel S. Marks
Henry Ford Hospital Medical Journal
Radionuclide examinations provide considerable information in evaluating patients who have received renal transplants. In the uncomplicated case, baseline data should be obtained so that subsequent changes in renal function can be better documented. In the complicated case, rapid delineation of the problem may result in more effective therapy. Serial examinations with several radiopharmaceuticals represent the best nuclear approach to the transplant patient. This paper describes the application and performance of these tests as currently performed at Henry Ford Hospital.
Histocompatibility Testing In Renal Transplantation, Hajime Hayashi, Jay B. Hunter
Histocompatibility Testing In Renal Transplantation, Hajime Hayashi, Jay B. Hunter
Henry Ford Hospital Medical Journal
The effect of HLA matching and other aspects of histocompatibility on renal graft survival were analyzed in 144 patients who received renal transplants at Henry Ford Hospital during the past ten years. Living related transplants with one haplotype match or better demonstrated a higher graft survival rate (at least 88%) at one year than the better matched cadaveric transplant. In cadaveric transplants, the group with fewer than two mismatched antigens appeared to have a higher graft survival rate than those with more than two. The patient population was not large enough to determine the effect of preformed antibodies, ABO grouping, …
Urological Complications In Renal Transplantation, Riad N. Farah, Richard Klugo, Thomas Mertz, Joseph C. Cerny
Urological Complications In Renal Transplantation, Riad N. Farah, Richard Klugo, Thomas Mertz, Joseph C. Cerny
Henry Ford Hospital Medical Journal
There were 116 renal transplants performed on 108 patients over a five-year period at Henry Ford Hospital with three major urological complications. The rate of 2.6% compares favorably with that reported in other series. Careful preoperative urological evaluation together with technically precise ureteroneocystostomy are factors that minimize the incidence of urological complications.
Treatment Of Uremic Diabetic Patients: Hemodialysis Or Transplantation?, Godofredo Santiago, Cosme Cruz, Francis Dumler, Pedro Cortes, Stanley Dienst, Sandra Parnell, Maxine Uniewski, Nathan W. Levin
Treatment Of Uremic Diabetic Patients: Hemodialysis Or Transplantation?, Godofredo Santiago, Cosme Cruz, Francis Dumler, Pedro Cortes, Stanley Dienst, Sandra Parnell, Maxine Uniewski, Nathan W. Levin
Henry Ford Hospital Medical Journal
Eighty-one patients with chronic renal failure associated with or secondary to diabetic nephropathy were treated with dialysis and/or transplant. Twenty-five had juvenile diabetes and 56 had adult onset diabetes. Juvenile diabetics did poorly on hemodialysis with 13 patients having a 19% four-year survival rate, whereas those who had cadaveric transplantation did well with a four-year patient and graft survival rate of 56% in nine patients. The three juvenile diabetics who received related kidney grafts are presently alive with good function. Patients with adult onset diabetes did well on hemodialysis with a four-year survival rate of 63% in 45 patients. In …
Intravenous Methylprednisolone For Kidney Transplantation, Krishna D. Valjee, Luis H. Toledo-Pereyra
Intravenous Methylprednisolone For Kidney Transplantation, Krishna D. Valjee, Luis H. Toledo-Pereyra
Henry Ford Hospital Medical Journal
The effect of different dosage levels (0-100 mg/k/day x 3)of intravenous methylprednisolone was tested in canine kidney autografts undergoing immediate contralateral nephrectomy. Intravenous methylprednisolone was safely administered in doses up to 40 mg/k/day for three days after kidney transplantation. Higher doses ( 40 mg/k/day x 3) were functionally and structurally harmful to canine kidney autografts.
Prolonging Kidney Graft Survival With Concanavalin A: Effects Of Temperature, Perfusate Composition, Ph, And Different Manufacturing Lots, Luis H. Toledo-Pereyra, Richard L. Simmons
Prolonging Kidney Graft Survival With Concanavalin A: Effects Of Temperature, Perfusate Composition, Ph, And Different Manufacturing Lots, Luis H. Toledo-Pereyra, Richard L. Simmons
Henry Ford Hospital Medical Journal
This study analyzes the effect of temperature, perfusate composition, pH, and variable manufacturing lots in prolonging kidney allograft survival with Concanavalin A (Con A). Cold temperature (4°C), crystalloid composition of the perfusates, and neutral or mildly alkaline pH were important factors in the effect of Con A on prolonging allograft survival. Also, different lots of Con A from the same manufacturer produced variable results in prolonging survival. Thus, multiple factors should be considered if Con A is to be used to prolong kidney allograft survival.
Reevaluation Of A New Colloid Hyperosmolar Solution For Hypothermic Storage Of Ischemic Canine Kidneys, Manuel Chee, Luis H. Toledo-Pereyra, Richard M. Condie
Reevaluation Of A New Colloid Hyperosmolar Solution For Hypothermic Storage Of Ischemic Canine Kidneys, Manuel Chee, Luis H. Toledo-Pereyra, Richard M. Condie
Henry Ford Hospital Medical Journal
This paper describes the results of experiments designed to test the effectiveness of a new colloid hyperosmolar solution (Toledo-Pereyra) for renal hypothermic storage. Three experimental conditions were employed: 60 minutes of warm ischemia (37 C), 24 hours of hypothermic storage, and a combination of warm ischemia and hypothermic storage. Canine kidneys tolerated either one of the first two procedures when flushed with the colloid hyperosmolar solution before storage or transplantation. If warm ischemia was applied before 24 hours of hypothermic storage, four of six dogs survived more than 20 days after transplantation, while the other two died of uremia. Thus, …
A Comparison Of Kidney Preservation Methods By Oxidative Phosphorylation Studies, Devprakash Samuel, Stanley G. Dienst
A Comparison Of Kidney Preservation Methods By Oxidative Phosphorylation Studies, Devprakash Samuel, Stanley G. Dienst
Henry Ford Hospital Medical Journal
An oxygen consumption assay using adenosine diphosphonucleotide (ADP) was performed on canine kidneys to measure the efficiency of oxidative phosphorylation. The purpose of the assay was to establish a respiratory control index (RCI) that could be used to evaluate kidneys preserved by different methods. Of the four methods tested, perfusion yielded the best results after 24-hour preservation. Additionally, four pairs of human cadaver kidneys were evaluated with the same assay. Some correlation existed between the RCI values of the nontransplanted kidney in each pair and the clinical viability of its transplanted mate.
Nutritional Aspects In The Care Of The Child With Cleft Lip And Palate, Mary E. Keitel
Nutritional Aspects In The Care Of The Child With Cleft Lip And Palate, Mary E. Keitel
Henry Ford Hospital Medical Journal
Proper nutrition is essential in the care of the infant with cleft lip or palate, as these infants are often plagued with feeding difficulties from birth. This paper reviews recent literature on the many feeding practices in use today and discusses the current trend toward a multidisciplinary approach to treatment for the cleft lip/palate child. It also presents a brief review of experimental animal studies which have implicated nutritional deficiences in the causation of cleft lip/palate.
Noninvasive Techniques In The Evaluation Of Arterial Disease, J. Dennis Baker
Noninvasive Techniques In The Evaluation Of Arterial Disease, J. Dennis Baker
Henry Ford Hospital Medical Journal
This paper reviews noninvasive technology currently being applied in clinical peripheral vascular laboratories for the evaluation of obstructive arterial disease in the lower extremities and in the cerebral circulation. Lower extremity, arterial insufficiency can be assessed by pressures measured with a Doppler flowmeter or by oscillometric tracings obtained with a Pulse Volume Recorder. Carotid artery stenosis is studied by: 1) ocular pneumoplethysmography, which indirectly measures ophthalmic artery pressure; 2) oculoplethysmography, which compares pulse arrival time at the two eyes; and 3) the Doppler ophthalmic test, which detects the flow pattern in the ophthalmic artery. The main uses of the tests …
What's New In Crohn's Disease Treatment, Francis J. Owens
What's New In Crohn's Disease Treatment, Francis J. Owens
Henry Ford Hospital Medical Journal
Progress in the management of Crohn's disease is limited by our inability to compare different patients. Two methods of evaluating the severity of disease have recently been published. Of these, the National Cooperative Crohn's Disease Study (NCCDS) method has been utilized in a study reported on at several national meetings but still in progress. Antibiotics in intensive prolonged dosage, e.g. ampicillin, 500 mg qid for several months, have recently been reported to benefit greater than 90% of patients not responding to conventional therapy. Metronidazole and dapsone continue to be mentioned in letters to journals. Sulfasalazine has been found useful in …
Emergency Transvenous Cardiac Pacing, Carl E. Bartecchi
Emergency Transvenous Cardiac Pacing, Carl E. Bartecchi
Henry Ford Hospital Medical Journal
A single pacemaker electrode catheter placement procedure, using the subclavian route and a semi-floating pacemaker catheter, was utilized in 120 consecutive patients who required emergency cardiac pacing. Stable pacing was achieved in a high percentage with few complications.