Life Sciences Commons^™

The Response Of Mice To Infection By The Parasitic Nematode Trichinella: A Comparison Of Trichinella Spiralis And Trichinella Pseudospiralis, Barry Clayton Anderson

Dissertations and Theses

The intracellular parasite Trichinella is a genus in phylum Nematoda that contains six named species including Trichinella spiralis and Trichinella pseudospiralis. These parasites infect a large variety of wild and domestic animals, human beings and a few species of birds. The parasitic strategies and the pathological effects on the host between trichinella spiralis and Trichinella pseudospiralis are quite different.

The purpose of this study is to gain an understanding of the physiological, immunological and pathological differences between these two species of Trichinella using infections in the mouse as a model. In the course of this research I have attempted to …

Characterization Of Early Activation Of Multi-Isotypic Antibody-Producing B Lymphocytes In The Small Intestine, Stephen Douglas Wagner

Theses Digitization Project

No abstract provided.

The Chemotactic Response Of Neutrophils To Components Of The Sera Of Mice Infected With Trichinella Spiralis, Sara Lynn Youngman

Dissertations and Theses

Neutrophils accumulate around Trichinella spiralis larvae encysted in skeletal muscle cells of the host. The magnitude of the neutrophil infiltration follows a pattern relating to the stage of infection of T.spiralis. This study was performed to determine if there are factors chemotactic for neutrophils present in the sera of mice infected with T.spiralis, and if present, to compare the chemotactic potential of sera from several time points during the infection. Female MRL++ mice hosted the T.spiralis infection and provided neutrophils for all experiments. The chemotactic potentials of sera were tested by placing 150 ul of serum collected …

Extracellular Matrix Proteins Of The Nurse Cell Capsule In Trichinella Spiralis Infections, Mary Louise Taylor

Dissertations and Theses

The infectious first-stage larvae of the nematode Trichinella spiralis is an intracellular parasite of altered skeletal muscle. Invasion of the muscle cell initiates a series of morphological changes in the host muscle cell which ultimately results in a specialized unit called the nurse cell. The completed nurse cell consists of a collagenous capsule, matrix of altered sarcoplasm, and a circulatory rete.

The purpose of this study was to determine the types of collagen present in the nurse cell capsule. Additionally, the presence of the glycoproteins, laminin and tenascin was determined. This study also sought to demonstrate the location of the …

The Influence Of Trichinella Spiralis Infection On Heat Shock Protein 72 Production In Mrl++ Mouse Intestinal Cells, Lisa Ann Kilejian

Dissertations and Theses

The production of Heat Shock Protein 72, the inducible for~ of the highly conserved 70 kilodalton heat shock protein family, was investigated in MRL++ mouse intestine during the two weeks of a Trichinella spiralis infection. Within hours of an oral infection using the encysted Trichinella spiralis found in the diaphragm of an infected mouse, the larvae are released from the cyst in the stomach. They travel to the intestine and burrow into the epithelial layer of the intestine. The jejunum is the primary site of the intestinal phase of trichinosis (Despommier 1983). This stage of infection in the jejunum was …

Characterization Of Early B Lymphocyte Activation During Trichinella Spiralis Infection In Rats, Elizabeth Margaret Richards

Theses Digitization Project

No abstract provided.