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Interleukin-6 And Exercise; Early Evidence Of A Novel Myokine, Brendan Hogg Mr.
Interleukin-6 And Exercise; Early Evidence Of A Novel Myokine, Brendan Hogg Mr.
Graduate Student Theses, Dissertations, & Professional Papers
Interleukin-6 (IL-6) was first identified as a pleiotropic cytokine, with a host of body-wide functions. Cytokine functions are characterized by chronically elevated levels within various inflammatory states. In this regard, IL-6 is largely associated with the acute phase response to many stimuli and performs specific actions when produced from certain cell types. Accrued evidence indicates IL-6 release from skeletal muscle often includes myokine functions. Novel myokine functions are adaptive in nature, and as compared to inflammatory/cytokine roles, exhibit a transient time course. Following exercise plasma IL-6 peaks and returns to resting levels within 1-2 hours. In contrast, IL-6 is observed …