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Articles 1 - 8 of 8
Full-Text Articles in Life Sciences
Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale, Nandhini Rajagopal
Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale, Nandhini Rajagopal
Dissertations - ALL
Biological barriers in the human body are one of the most crucial interfaces perfected through evolution for diverse and unique functions. Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological consequences, their intact presence also poses a challenge to effective delivery of therapeutic drugs. Complimenting a rigorous combination of in vitro and in vivo approaches to establishing the fundamental biological construct, in addition to elucidating pathological implications …
Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale, Nandhini Rajagopal
Computational Algorithms For Predicting Membrane Protein Assembly From Angstrom To Micron Scale, Nandhini Rajagopal
Dissertations - ALL
Biological barriers in the human body are one of the most crucial interfaces perfected through evolution for diverse and unique functions. Of the wide range of barriers, the paracellular protein interfaces of epithelial and endothelial cells called tight junctions with high molecular specificities are vital for homeostasis and to maintain proper health. While the breakdown of these barriers is associated with serious pathological consequences, their intact presence also poses a challenge to effective delivery of therapeutic drugs. Complimenting a rigorous combination of in vitro and in vivo approaches to establishing the fundamental biological construct, in addition to elucidating pathological implications …
The Role Of Nutrition And Hormone Signaling In Extended Larval Development And Obesity In Starvation-Selected Drosophila Melanogaster, Jennifer M. Clark
The Role Of Nutrition And Hormone Signaling In Extended Larval Development And Obesity In Starvation-Selected Drosophila Melanogaster, Jennifer M. Clark
UNLV Theses, Dissertations, Professional Papers, and Capstones
Brief periods of starvation are a common stressor that most animals encounter in the wild and must be able to survive in order to maximize their fitness. Starvation resistance of the adult fruit fly, Drosophila melanogaster, is thought to be primarily conferred by adult fat stores, body size, metabolic rate, behavior, and activity levels. Additionally, flies selected for starvation resistance also often show delayed pupariation, which is usually indicative of altered hormone signaling. How starvation selection extends development and if it contributes to adult starvation resistance remains incompletely studied. Identifying the targets of starvation selection that cause extended development and …
Investigation Into The Akirin Subcellular Localization And Developmental Interactions, Riley Wildeman
Investigation Into The Akirin Subcellular Localization And Developmental Interactions, Riley Wildeman
Master of Science in Integrative Biology Theses
Akirin is a highly conserved nuclear protein ubiquitously expressed in nonfungal eukaryotic species and is known to be involved in many biological processes such as embryonic muscle patterning and innate immune function. Akirin functionality is essential for the prevention of disease and developmental defects. This investigation focused on both the subcellular localization of Akirin based on a putative nuclear localization signal and the genetic interaction between Akirin and the Nucleosome Remodeling Deacetylase (NuRD) complex. Through transfection of Drosophila S2 cells with Akirin mutant constructs we were able to visualize the localization patterns of Akirin and how the patterns relate to …
Variability Of The Proximate And Protein Composition Of Camel Milk (Camelus Dromedarius), Huda Musa Elsayed Mohamed
Variability Of The Proximate And Protein Composition Of Camel Milk (Camelus Dromedarius), Huda Musa Elsayed Mohamed
Dissertations
Dromedary camel milk (Camelus dromedarius) has unique physical, nutritional, and technological properties when compared with other milk. Unlike bovine milk, the processing of camel milk into fermented products and its treatment using ultra-high temperatures is technically challenging. Therefore, this research aimed to determine the variability in the proximate composition and the protein composition of camel milk collected from individual animals that are reared under intensive management in the UAE. To determine the proximate composition of samples (n = 217) were analyzed by NIR and MIR spectroscopy methods. The results obtained by the two methods were also compared. The …
Biophysical Characterization Of The Par-4 Tumor Suppressor: Evidence Of Structure Outside The Coiled Coil Domain And Interactions With Platinum Chemotherapeutics, Andrea Megan Clark
Biophysical Characterization Of The Par-4 Tumor Suppressor: Evidence Of Structure Outside The Coiled Coil Domain And Interactions With Platinum Chemotherapeutics, Andrea Megan Clark
Chemistry & Biochemistry Theses & Dissertations
Prostate apoptosis response-4 (Par-4) is an apoptosis-inducing tumor suppressor protein. Full-length Par-4 has previously been shown to be a predominantly intrinsically disordered protein (IDP) under neutral conditions, with significant regular secondary structure evident only within the C-terminal coiled coil domain. However, IDPs can gain ordered structure through the process of induced folding, which often occurs under non-neutral conditions. Previous work has shown that the Par-4 leucine zipper, which is a subset of the C-terminal coiled coil domain, is disordered under neutral conditions, but forms a dimeric coiled coil at acidic pH. Increase in ionic strength was also shown to increase …
Establishing And Validating Methods To Assess The Influence Of Exercise On Circulating Exosome Profiles In Sedentary Older Adults, Heather Quiriarte
Establishing And Validating Methods To Assess The Influence Of Exercise On Circulating Exosome Profiles In Sedentary Older Adults, Heather Quiriarte
LSU Master's Theses
Aging is associated with progressing cellular structural and functional changes, and sedentary behavior can exacerbate these hallmarks of aging. Routine exercise is known to have beneficial effects on physiological systems, but the exact molecular mechanisms behind the health benefits are unclear. Emerging evidence suggests extracellular vesicles called exosomes are involved in the intercommunication between cells and organs following exercise by delivering their cargo such as proteins and miRNAs. miRNA profiles in older adults following acute and chronic exercise need further exploration. Specifically, the effects of regular low-intensity physical activity (LPA) breaks in sedentary time on proteins and miRNA packaged in …
Characterization Of Yellow Family Proteins In Gryllus Bimaculatus, Alexandra W. Rubenstein
Characterization Of Yellow Family Proteins In Gryllus Bimaculatus, Alexandra W. Rubenstein
Honors Projects
Neuronal plasticity occurs in developing nervous systems, with adult organisms rarely able to recover from neurological damage. The cricket, Gryllus bimaculatus, is useful to study neuronal plasticity due to its reorganization of the auditory system in response to injury beyond development. When a cricket ear is removed and auditory afferents severed, a rare phenomenon occurs: the dendrites of interneurons on the deafferented side cross the typically-respected midline of the prothoracic ganglion to form functional synapses with auditory afferents from the opposite side. To find proteins involved in this phenomenon, the Horch Lab assembled a de novo transcriptome from neurons in …