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Full-Text Articles in Life Sciences
Structure Activity Relationship Studies Of An Anticryptosporidial Drug, Kirtika Chatri
Structure Activity Relationship Studies Of An Anticryptosporidial Drug, Kirtika Chatri
Graduate College Dissertations and Theses
Cryptosporidium is an apicomplexan parasite responsible for waterborne outbreaks of diarrheal disease worldwide. There are two species of Cryptosporidium that are important enteric pathogens for humans. The disease, Cryptosporidiosis, is a major cause of childhood diarrhea and an important factor in childhood malnutrition and also a high rate of death (Sparks et al., 2015). It is also more frequent and severe in malnourished children under 3 years of age and immune-compromised individuals, such as AIDS and transplant patients. A common treatment which has greatly reduced diarrhea-associated mortality is oral rehydration therapy; however, enteric infections still persist (Guerrant, DeBoer, Moore, Scharf, …
Network And Cellular Effects Of The Mu Opioid Receptor In Cortical Interneurons, Adrian Dutkiewicz
Network And Cellular Effects Of The Mu Opioid Receptor In Cortical Interneurons, Adrian Dutkiewicz
Graduate College Dissertations and Theses
The µ opioid receptor (µOR) exerts a powerful excitatory effect in cortical circuits and cultured neurons by promoting glutamatergic activity after binding endogenous or exogenous opioids. While most research indicates that the receptor does this by decreasing activity or output of GABAergic interneurons that inhibit glutamate-releasing Pyramidal Neurons, other experiments suggest that the µOR directly upregulates excitatory Pyramidal Neurons instead. Thus, the cellular target of cortical opioid agonists remains unclear, and the µOR’s net excitatory mechanisms are not fully understood. Consequently, utilizing electrophysiology to detect µOR responses to the specific agonist [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin (DAMGO) has yielded incomplete information on …
Analysis Of Intracellular Calcium Events In Hypothalamic Neurons, Samantha Kolowrat
Analysis Of Intracellular Calcium Events In Hypothalamic Neurons, Samantha Kolowrat
Graduate College Dissertations and Theses
The paraventricular nucleus of the hypothalamus (PVN) plays a critical role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, sympathetic activity, cardiovascular system and stress responses.1,2 This brain region is primarily controlled by GABA and glutamate inputs from the peri-PVN region.3 Two significant modulators of these GABA-glutamate systems are Angiotensin II (Ang II) and brain derived neurotrophic factor (BDNF). It has been postulated that BDNF and Ang II signaling rely on each other via cross-activation of their receptors and by activation of the non-selective cation channel, the transient receptor channel type C3 (TRPC3).This thesis aims to study changes in intracellular calcium levels …
Designer Biologics Composed Of Hepatocyte Growth Factor, Fibroblast Growth Factor 2 And Immunoglobulin G For Treatment Of Acute Myocardial Infarction, Benjamin Liebman
Designer Biologics Composed Of Hepatocyte Growth Factor, Fibroblast Growth Factor 2 And Immunoglobulin G For Treatment Of Acute Myocardial Infarction, Benjamin Liebman
Graduate College Dissertations and Theses
ABSTRACT Coronary artery disease leading to myocardial infarction (a.k.a. MI, heart attack) is one of the leading causes of death globally. Each year an estimated 605,000 Americans suffer a heart attack, which equates to one MI every 40 seconds. As such, MI represents one of the largest health burdens to society. The current standard of care is revascularization therapy achieved by fibrinolytics and Percutaneous Coronary Intervention (PCI); both of which re-open occluded proximal arteries to restore blood flow to the affected areas. Despite revascularization therapy, 30-50% of patients exhibit a form of reperfusion injury termed “no/low-reflow” in which the blood …
Functional Characterization Of Leptomeningeal Anastomoses In Physiological Condition And Chronic Hypertension, Zhaojin Li
Graduate College Dissertations and Theses
Stroke is the second leading cause of death worldwide and the leading cause of devastating disability. Leptomeningeal anastomoses (LMAs) are small distal anastomotic vessels, also known as pial collaterals in the brain. These vessels redirect blood flow during an occlusion and are important for stroke treatment and outcome. Hypertension, a major risk factor for stroke, is associated with limited amounts of salvageable tissue, greater perfusion deficit and worse stroke outcome. Angiotensin II (Ang II), generated from angiotensin I by angiotensin converting enzyme (ACE), is importantly involved in the pathogenesis of hypertension. Despite the important clinical implications, functions of LMAs in …