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Cerebrovascular Compliance In Humans, Marcy Erin Moir
Cerebrovascular Compliance In Humans, Marcy Erin Moir
Electronic Thesis and Dissertation Repository
Pulsatile blood flow consists of two components: steady flow and oscillatory flow. Steady blood flow is primarily regulated by vascular resistance while vascular compliance represents a key mediator of oscillatory blood flow. However, most studies investigating the regulation of cerebral blood flow in humans have focused on vascular resistance. Recently, emerging evidence has implicated vascular compliance as an important contributor to the regulation of cerebral perfusion. Therefore, the research contained herein aimed to i) quantify cerebrovascular compliance responses to blood pressure alterations and ii) explore mechanisms regulating cerebrovascular compliance in humans. The studies employed a Windkessel modelling approach to calculate …
Non-Invasive Quantification Of Cerebral Oxygen Metabolism By Hybrid Positron Emission Tomography/Magnetic Resonance Imaging, Lucas Diovani Lopes Narciso
Non-Invasive Quantification Of Cerebral Oxygen Metabolism By Hybrid Positron Emission Tomography/Magnetic Resonance Imaging, Lucas Diovani Lopes Narciso
Electronic Thesis and Dissertation Repository
Although positron emission tomography (PET) remains the gold standard for quantifying cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2), the procedures are invasive and complex, requiring arterial sampling and accounting for blood-borne activity. Non-invasive methods generally require extracting an image-derived input function (IDIF) from the carotid arteries; however, these methods are sensitive to partial volume errors due to the poor spatial resolution of PET. Hybrid PET/magnetic resonance imaging (MRI) offers an alternative non-invasive approach by using MRI to calibrate PET data. PET/MR imaging of oxidative metabolism (PMROx) is a reference-based approach that uses whole-brain (WB) …