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Full-Text Articles in Life Sciences
Daphnia Pulex: The Mixed Messages Of Mutations , Matthew Randall Bruner
Daphnia Pulex: The Mixed Messages Of Mutations , Matthew Randall Bruner
Theses and Dissertations
While mutations are almost universally considered to be more often deleterious than beneficial, their precise interactions between different populations and individual lines have been largely overlooked. Using mutation accumulation lines of four clones of obligately asexual Daphnia pulex, this research is intended to investigate the degree to which spontaneous mutation would affect fitness-related traits after roughly 100 generations. The expectation was that there would be a visible decrease in juvenile specific growth rate, the surrogate measurement used for fitness, across all four clones due to the deleterious nature of mutation in a selection free environment. Through measuring birth mass in …
Effect Of Oxidative Stress On Lifespan And Cellular Survival, Benedicth Onyeka Ukhueduan
Effect Of Oxidative Stress On Lifespan And Cellular Survival, Benedicth Onyeka Ukhueduan
Theses and Dissertations
When cells experience oxidative stress, the integrated stress response (ISR) signaling pathway is activated. One of the first outcomes of such ISR-activated response is to temporarily halt protein synthesis, which aids in cellular recovery. However, if cells cannot recover from the stress, they activate the cell death pathways which kills the affected cells, usually by apoptosis, which can then lead to either acquisition or prevention of diseases depending on the situation. In physiological aging, a compromised stress response is observed as an organism ages, which leads to disrupted homeostasis and elevated risk of disease. Thus, longevity of an organism is …