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Full-Text Articles in Life Sciences

Identification Of Proteins That Contribute To Yeast Heat Stress By Lysine Acetylation, Weijia Shi May 2021

Identification Of Proteins That Contribute To Yeast Heat Stress By Lysine Acetylation, Weijia Shi

Biological Sciences Undergraduate Honors Theses

Evidence is emerging that protein lysine acetylation may be a novel type of post-translational modification (PTM) contributing to the mechanisms of yeast heat stress responses. Proteomics studies including ours have identified over 1,000 acetylated proteins in the yeast proteomes that are composed of about 6,000 proteins. Our lab recently identified 596 proteins that underwent acetylation changes during heat shock by mass spectrometry. However, the role of lysine acetylation on specific residues of specific proteins in yeast thermotolerance remains largely unknown. This study selected 43 proteins from our lab’s previous work and examined their possible contributions to yeast heat stress responses. …


Comparing Cognition In Women Between The Ages Of (18-40) And (40-70), Annalyn Smith May 2021

Comparing Cognition In Women Between The Ages Of (18-40) And (40-70), Annalyn Smith

Biological Sciences Undergraduate Honors Theses

Currently, 5.8 million Americans are living with Alzheimer’s disease (AD), which is a degenerative brain disease. It is currently the sixth-leading cause of death in the United States (Alzheimer’s Association, 2019). AD also possesses a financial burned on the United States, estimated to cost $290 billion in 2019. Sufferers of AD insidiously lose their memory, personality, and judgment abilities until there are no longer recognizable by their loved ones. Currently, the best chance suffers of AD have is to catch the disease early on to slow its effects. This is due to the fact that treatment can only prevent and …


How Acetylation Regulates Metabolic Enzyme Function During Environmental Shifts, Jared Canonigo May 2021

How Acetylation Regulates Metabolic Enzyme Function During Environmental Shifts, Jared Canonigo

Biological Sciences Undergraduate Honors Theses

Organisms such as Saccharomyces cerevisiae can regulate the mechanisms of proteins through post-translational modification. These modifications play a vital role in functional proteomic activity because they can regulate protein activity, localization, and interaction with other cellular molecules. Such modifications include phosphorylation, methylation, and acetylation. The metabolic mechanisms of yeast became of keen interest to our lab because our lab noticed many stress defense proteins were being acetylated during stress heat shock. Notably, Adh1p and Adh2p showed both an increase and a decrease in acetylation at two lysine residues (K315 and K314) overtime during heat shock respectively, though the exact function …


Temperature-Dependent Macrophage Activity In Rainbow Trout, Danica Mcgrevey May 2021

Temperature-Dependent Macrophage Activity In Rainbow Trout, Danica Mcgrevey

Biological Sciences Undergraduate Honors Theses

Fever is an essential component of the immune response. Fever enhances immune responses as well as creates an environment in which the body has advantages over pathogens. Macrophages are often the first cells that come in contact with pathogens, as they reside in tissues. They are important for their engulfment of pathogens that results in the digestion of the pathogen, but they also produce nitric oxide and cytokines that contribute to immune response in a variety of ways, including initiating adaptive immunity and directing the production and activity of other immune cells. We were curious about macrophages from other temperature …


Examining The Invasion Of A Bush Honeysuckle Using Climate Analysis, Andrew Palmer May 2021

Examining The Invasion Of A Bush Honeysuckle Using Climate Analysis, Andrew Palmer

Biological Sciences Undergraduate Honors Theses

Within the study of invasive plants, particular importance is placed on elucidating the mechanisms by which these plants proliferate and dominate within their introduced ranges. Several theories have been advanced to explain these invasions, each with different implications for the predicted range of invasive plants. Recent studies have provided support for the application of several invasion theories to Lonicera maackii, or what is more commonly referred to as bush honeysuckle. This species provides a unique opportunity to examine the efficacy of these theories in explaining the range expansion of invasive plants. L. maackii is endemic to eastern Asia, but …