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Full-Text Articles in Life Sciences
The Shape Of Metabolism: Mitochondrial Dynamics, Remodeling, And Bioenergetic Reprogramming In Disease, Carl Decker
The Shape Of Metabolism: Mitochondrial Dynamics, Remodeling, And Bioenergetic Reprogramming In Disease, Carl Decker
KGI Theses and Dissertations
Mitochondria are dynamic, double-membrane bound hubs of bioenergetics, cell signaling, and redox balance that exist as an oscillating network of fused superstructures and smaller, single organelles. Importantly, their position at the junction of catabolic and anabolic metabolism connects these morphological fluctuations to larger cellular metabolic programs, which in turn have implicated mitochondrial dynamics in a number of disease states and a varied set of cell phenomena. For example, differentiation of memory t-cells is dependent on mitochondrial network morphology, and in particular on remodeling dynamics that yield fused mitochondrial assemblies favoring oxidative phosphorylation-driven metabolism. In contrast, many cancers have been shown …
Do Didymosphenia Geminata Blooms Affect Fishes In The Kootenai River Basin?, Niall G. Clancy
Do Didymosphenia Geminata Blooms Affect Fishes In The Kootenai River Basin?, Niall G. Clancy
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Didymosphenia geminata (Didymo) is a nuisance algae that can cover entire streambeds under certain environmental conditions. Numerous studies have shown that it changes the composition of stream invertebrates. Fishes in many headwaters are known to feed almost exclusively on invertebrates. Thus, there is concern changes to the amount or type of invertebrates caused by Didymo blooms will impact fishes such as trout, charr, and sculpin. In the Kootenai River basin of Montana and British Columbia, we examined stream invertebrates and fish diets, condition, and growth across 25 streams during the summers of 2018 and 2019. The severity of Didymo blooms …
Mitochondrial Deletions And Their Disease-Causing Effects, Austin Bell
Mitochondrial Deletions And Their Disease-Causing Effects, Austin Bell
Biological Sciences Undergraduate Honors Theses
The mitochondria perform a plethora of important functions within the cell, with one of the most paramount being ATP production. Deregulation of its function can have dire consequences on cellular functions. Mutations such as deletions within the mitochondrial DNA (mtDNA) can cause disease within the patients affected. These diseases often affect children, causing symptoms such as gradual loss of eyesight and hearing, diabetes, and other problems that lower the quality of life. The mitochondria are also very dynamic organelles that undergo rounds of fission and fusion to keep up with the metabolic needs of cells, necessitating a homeostatic balance between …
Bioenergetic Mechanisms Of Age-Related Differences In Muscle Fatigue, Liam F. Fitzgerald
Bioenergetic Mechanisms Of Age-Related Differences In Muscle Fatigue, Liam F. Fitzgerald
Doctoral Dissertations
Muscle fatigue is defined as the reduced capacity to produce torque or power in response to contractile activity. Previous work has observed greater fatigue in older than young adults in response to high-velocity contractions, but similar fatigue with age in response to moderate-velocity contractions. The mechanisms for these age-related differences is not clear. One potential explanation is a greater accumulation of putative agents of fatigue (e.g., Pi, H2PO4-, and H+) in older than young muscle during high- but not moderate-velocity contractions. Older muscle may accumulate these metabolites to greater extent because of deficits …
Seasonal Variation In Mitochondrial Bioenergetics Of The Bluegill Sunfish, Lepomis Macrochirus, From A Shallow Midwest River, Derick Isaac Lamptey
Seasonal Variation In Mitochondrial Bioenergetics Of The Bluegill Sunfish, Lepomis Macrochirus, From A Shallow Midwest River, Derick Isaac Lamptey
Masters Theses
As average global temperature increase, the frequency and magnitude of extreme temperatures in shallow aquatic ecosystems are more ubiquitous. In order to understand how these changing thermal regimes affect aquatic ectotherms, it is essential to develop studies evaluating the response of ectotherms to seasonal fluctuating thermal regimes. Previous studies on fluctuating temperature regimes have reported an increased physiological stress leading to morphological, behavioral and biochemical adaptations. From the latter, the adaptive capacity and seasonal performance associated with optimal function of the oxidative phosphorylation system (OXPHOS) are key for species persistence. However, studies on this matter are scarce. This study explores …