Open Access. Powered by Scholars. Published by Universities.®

Life Sciences Commons

Open Access. Powered by Scholars. Published by Universities.®

Articles 1 - 7 of 7

Full-Text Articles in Life Sciences

2-D Electrophoresis Modeling Of Multienzyme Cutting Of Polypeptides, Howard Mayes Oct 2017

2-D Electrophoresis Modeling Of Multienzyme Cutting Of Polypeptides, Howard Mayes

Theses

2-Dimensional Electrophoresis is one of the tools in the identification of proteins by molecular weight and pH. The display of molecular weight allows the researcher to quickly identify whether a specific protein or peptide string is in the sample. The pH measurement allows even better resolution between different species in the sample. The MultiEnzyme ElectroPhoresis (MEEP) program tries to model that by providing a graph that displays separated protein strings by both molecular weight and pH. The ability to cleave the protein with 43 different enzyme variations allows the researcher to analyze appropriate enzymes to isolate a protein subsequence before …


Biophysical Mechanisms Of Frequency-Dependence And Its Neuromodulation In Neurons In Oscillatory Networks, David Michael Fox Oct 2017

Biophysical Mechanisms Of Frequency-Dependence And Its Neuromodulation In Neurons In Oscillatory Networks, David Michael Fox

Dissertations

In response to oscillatory input, many isolated neurons exhibit a preferred frequency response in their voltage amplitude and phase shift. Membrane potential resonance (MPR), a maximum amplitude in a neuron’s input impedance at a non-zero frequency, captures the essential subthreshold properties of a neuron, which may provide a coordinating mechanism for organizing the activity of oscillatory neuronal networks around a given frequency. In the pyloric central pattern generator network of the crab Cancer borealis, for example, the pacemaker group pyloric dilator neurons show MPR at a frequency that is correlated with the network frequency. This dissertation uses the crab …


Experiment-Based Quantitative Modeling For The Antibacterial Activity Of Silver Nanoparticles, Mohammad Aminul Haque Aug 2017

Experiment-Based Quantitative Modeling For The Antibacterial Activity Of Silver Nanoparticles, Mohammad Aminul Haque

Graduate Theses and Dissertations

Silver (Ag) has been well known for its antimicrobial activity for a long time. Recent research showed the potential of Ag nanoparticles as emerging antimicrobial agents. However, little quantitative analysis has been performed so far to decipher the mechanism of interaction between nanoparticles and bacteria. Here, a detailed analysis based on kinetic growth assay and colony forming unit assay has been carried out to study the antimicrobial effect of Ag nanoparticles against Escherichia coli (E. coli) bacteria. It was observed that the presence of Ag nanoparticles increased the lag time of bacterial growth while not affecting the maximum growth rate …


Dengue Vaccination Modulates The Dengue-Zika Viral System Via Immunogenic Cross-Talk, Noah J. B. Silva Jul 2017

Dengue Vaccination Modulates The Dengue-Zika Viral System Via Immunogenic Cross-Talk, Noah J. B. Silva

Biology ETDs

A vaccine for dengue, a viral disease which is a major driver of morbidity and mortality in tropical and subtropical regions, has recently been approved by eleven countries. While vaccination has the potential to reduce disease burden, the approved vaccine faces challenges due to the interactions between the four serotypes of dengue virus (DENV1-4) and the potential interactions with Zika virus (ZIKV), a related flavivirus. In this study, we propose a mathematical model incorporating both DENV and ZIKV in order to investigate the effects of viral competition on dengue vaccine performance, the potential for change in incidence of Zika due …


More Than Food: An Analysis Of Multidimensional Relationships In Our Food System, Jessica Erin Newnan Jan 2017

More Than Food: An Analysis Of Multidimensional Relationships In Our Food System, Jessica Erin Newnan

Honors Theses and Capstones

Food is an integral part of everyday life for human beings, thus meriting particular attention from research and education. Looking further in depth at the factors that influence food, it becomes apparent that this is a complex topic that is related to several systems within the constructs of society. Here, the food system is approached with the understanding that several systems influence food consumption options and decisions including the agricultural, economic, education, energy, health, and political systems. To identify the relationships more closely, a three-dimensional model was built to represent the food system and depict several key factors, their relationships, …


Multiscale Habitat Suitability Modeling For Canary Rockfish (Sebastes Pinniger) Along The Northern California Coast, Portia N. Saucedo Jan 2017

Multiscale Habitat Suitability Modeling For Canary Rockfish (Sebastes Pinniger) Along The Northern California Coast, Portia N. Saucedo

Cal Poly Humboldt theses and projects

Detailed spatially-explicit data of the potential habitat of commercially important rockfish species are a critical component for the purposes of marine conservation, evaluation, and planning. Predictive habitat modeling techniques are widely used to identify suitable habitat in un-surveyed regions. This study elucidates the predicted distribution of canary rockfish (Sebastes pinniger) along the largely un-surveyed northern California coast using data from visual underwater surveys and predictive terrain complexity covariates. I used Maximum Entropy (MaxEnt) modelling software to identify regions of suitable habitat for S. pinniger greater than nine cm in total length at two spatial scales. The results of …


An Estimation Of Potential Salmonid Habitat Capacity In The Upper Mainstem Eel River, California, Emily J. Cooper Jan 2017

An Estimation Of Potential Salmonid Habitat Capacity In The Upper Mainstem Eel River, California, Emily J. Cooper

Cal Poly Humboldt theses and projects

In Northern California’s Eel River watershed, the two dams that make up the Potter Valley Project (PVP) restrict the distribution and production of anadromous salmonids, and current populations of Chinook Salmon (Oncorhynchus tshawytscha) and steelhead trout (O. mykiss) in the upper mainstem Eel River are in need of recovery. In anticipation of the upcoming FERC relicensing of the PVP, this project provides an estimation of the extent of potential salmonid habitat and its capacity for steelhead trout and Chinook Salmon in the upper mainstem Eel River watershed above the impassable Scott Dam. Using three fish passage …